# Bullseye Rash: Tick Bite and Lyme Disease Signs
A bullseye rash is a red skin lesion that expands around the site of a tick bite, often with a paler center. Medical literature calls this lesion erythema migrans, and it is the earliest clinical sign of Lyme disease in people [1][2]. If you develop one, see a clinician promptly. Early Lyme disease is usually treated with antibiotics, and treatment is most effective when it starts soon after the rash appears.
This guide covers the human bullseye rash in depth: what it looks like, how it changes over days, when it appears after a bite, which conditions imitate it, and when to seek care. It closes with a short comparison to [Lyme disease in dogs](/knowledge/veterinary-medicine/clinical-methods/lyme-disease-in-dogs), because many readers arrive here after finding a tick on a pet or after a shared walk in tall grass. Dogs can get Lyme disease, but they rarely develop the rash that makes the human disease so recognizable. If you are reading this because of a rash on your own skin, your next step is a medical appointment, not a veterinary one.
This article is educational and is not a substitute for veterinary diagnosis or treatment.
## The Direct Answer: What a Bullseye Rash Means
A bullseye rash is the hallmark skin sign of early Lyme disease, a bacterial infection spread by the bite of an infected Ixodes tick [3][1]. The rash usually appears 3 to 30 days after the bite, expands slowly over days, and may clear in the center to create a target or bullseye pattern [4]. Not every Lyme rash forms a perfect bullseye. Many are solid red patches that simply grow. For that reason, clinicians treat an expanding rash plus a plausible tick exposure as a clinical diagnosis even when the shape is imperfect [5][6].
Three practical points summarize the topic.
1. The rash is a clinical marker. In an endemic area, an expanding rash after tick exposure is often enough to diagnose early Lyme disease without waiting for laboratory results [5].
2. Timing matters. A tick usually needs to stay attached for a day or more before it can pass Borrelia bacteria into your bloodstream. A tick you find and remove within hours is unlikely to have transmitted infection. The classic estimate is 24 to 48 hours of attachment.
3. Delayed care carries risk. Untreated Lyme disease can spread to joints, the nervous system, and the heart. One report describes a young man who developed a third-degree heart block weeks after a tick bite and an expanding rash [7].
## At a Glance: Bullseye Rash Versus Its Look-Alikes
Use this table as a quick orientation. It cannot replace an in-person skin exam, but it helps you sort the most common ring-shaped and red lesions people confuse with a Lyme rash.
| Feature | Erythema migrans (Lyme) | Ringworm (tinea) | Cellulitis | Spider bite | Allergic reaction |
|--|--|--|--|--|--|
| Typical onset after exposure | 3 to 30 days after tick bite | Days to weeks, no tick link needed | Hours to days after a break in skin | Minutes to hours after bite | Minutes to hours after contact or sting |
| Shape | Expanding ring, may have central clearing | Ring with scaly, raised edge | Spreading redness without a clean ring | Red bump or blister, sometimes with a dark center | Raised welts, hives, or diffuse redness |
| Surface | Usually flat or slightly raised, warm | Scaly, itchy, flaky | Tender, hot, swollen | Tender, may ulcerate | Itchy, raised, may move around |
| Itch | Mild or absent | Often itchy | Painful rather than itchy | Painful | Very itchy |
| Spread | Grows over days to weeks | Grows slowly outward | Spreads fast over hours | Local, then may blister | Can spread rapidly across the body |
| Urgency | See a clinician soon | Routine care | Urgent if fever or rapid spread | Urgent if systemic symptoms | Emergency if breathing trouble or facial swelling |
A single row in this table will not settle the question for any one person. Two conditions can overlap, and a person can have both a tick bite and an unrelated rash. A clinician weighs the shape, the timeline, the location, and any systemic symptoms together.
## What Erythema Migrans Actually Looks Like
The classic bullseye erythema migrans rash, the hallmark sign of early Lyme disease at the tick bite site. Image: Photo Credit: James Gathany Content Providers(s): CDC/ James Gathany, Public domain, via Wikimedia Commons.
Erythema migrans is the medical term for the expanding red lesion of early Lyme disease. A recent clinical review describes it as the hallmark symptom of the disease, and notes that it sometimes shows the central clearing that gives the bullseye its name [4]. When the rash is textbook, diagnosis is straightforward. When it is not, clinicians rely on exposure history and other findings [4][3].
The look varies more than most people expect.
### Classic central clearing
In the classic form, the rash begins as a red spot or papule at the bite site, then expands outward while the middle fades to normal skin color. This leaves a red outer ring with a lighter center, the pattern most people picture when they hear bullseye rash or bull's eye tick bite. The ring is usually flat or only slightly raised, and it may feel warm. Itching and pain are often mild or absent, which is one reason people delay seeking care.
### Solid expanding patches
Many Lyme rashes never clear in the middle. They present as uniformly red or pink patches that grow steadily outward. Clinical guidance emphasizes that early recognition rests on the characteristic rash and exposure to an endemic area, and that the expanding behavior matters as much as the shape [5]. A solid red patch that doubles in size over a few days after a known tick bite deserves the same attention as a perfect target lesion.
### Where the rash appears
The lesion forms at the site of the tick bite. Ticks often attach in skin folds and hidden areas, including the groin, armpits, waistband, behind the knees, and along the hairline. A rash in one of these locations is easy to miss unless you look deliberately. A review of confirmed acute Lyme cases in England found that many people never realized they had been bitten at all [8]. The same study reported that bites were frequently acquired close to home, in gardens and local green spaces, rather than during travel [8].
### Color and skin tone
The rash may be less visible on darker skin, where redness is subtler and can read as a bruise or a patch of darkened skin. Research with people of color diagnosed with Lyme disease found that diagnostic delays were attributed in part to the erythema migrans rash being harder to see on darker skin [9]. A separate analysis of medical teaching images found that almost all erythema migrans photographs used in top-tier U.S. medical schools showed light skin, with only two of sixteen resources including an image on dark skin [10]. Reading material cannot fully substitute for an in-person exam, and the takeaway for patients is straightforward. If you have an expanding skin change after a tick bite and the color looks unusual, describe the timeline and the tick exposure clearly to your clinician.
### The lesion can suggest more than a skin problem
Erythema migrans is a sign of active infection, not just a local skin reaction [2]. The immune response in the lesion involves clonally expanded T cells that produce inflammatory signals, which is part of how the body fights the spirochete [2]. Because the infection is systemic from early on, some people develop additional lesions at sites distant from the original bite. Fever, headache, muscle aches, and fatigue may accompany the rash. A case report from inland China described a patient whose early expanding lesion went unrecognized for over a year before more severe disease developed [11]. That scenario is uncommon, but it shows why early recognition matters.
## The Timeline: From Tick Bite to Rash to Diagnosis
The sequence from bite to rash is one of the most useful things to understand, because the timing narrows the list of possibilities.
### Attachment and transmission
Borrelia bacteria live in the tick's gut. When the tick feeds, the bacteria migrate to the salivary glands and enter the host. This process takes time. A tick that remains attached for less than a day is unlikely to transmit infection, and the widely cited window is 24 to 48 hours of attachment. This is why a careful tick check after time outdoors is genuinely protective. It is also why finding a tick does not automatically mean infection, and why a rash that appears hours after a bite is usually a local reaction rather than erythema migrans.
### Incubation
After transmission, the rash typically appears 3 to 30 days later [4]. Systemic symptoms such as fever and aching can begin before the rash or at the same time. A patient in one report developed a migrating rash roughly a month before presenting with cardiac complications [7]. A case report from China described an expanding lesion that followed a tick bite by many months before the patient became critically ill [11]. The takeaway is that a remembered tick bite weeks in the past stays relevant when a new expanding rash appears.
### Growth over days
An important distinguishing feature is rate of growth. Erythema migrans expands gradually, usually over days, reaching several centimeters in width. A lesion that appears fully formed in an hour and fades by evening behaves like an allergic reaction, not erythema migrans. A lesion that grows steadily over two or three days while looking flat and warm fits Lyme disease better.
### Diagnosis and delay
Diagnosis of early Lyme disease is clinical when the rash is present [5][6]. When the rash is absent or unclear, clinicians rely on symptoms, exposure history, and serologic testing [6]. Laboratory testing has known limits in early disease. In one study of well-characterized early Lyme samples, sensitivity of the initial blood draw algorithms ranged from 22 percent to 36 percent, while specificity was high [12]. Later-stage samples perform better. Clinicians manage this by treating a characteristic rash promptly rather than waiting for confirmatory testing.
Delay is common. A Japanese surveillance study found a median of 28.5 days from symptom onset to diagnosis, with many patients presenting with nonspecific symptoms [13]. Some of that delay reflects that the rash is not always recognized [8]. A rash you notice on day two is a chance to shorten that interval.
## Why Some Ticks Transmit Borrelia and Others Do Not
Lyme disease is caused by spirochetes in the Borrelia burgdorferi sensu lato complex, spread by Ixodes ticks [1]. The complex includes several species found across North America, Europe, Asia, and parts of South America and Africa [1]. Not every tick carries the bacteria, and not every bite transmits infection. Three factors shape the risk.
1. Tick species and geography. Only certain Ixodes species transmit Lyme disease, and they are not present everywhere. Endemic regions have higher rates of infected ticks. In England, a surveillance study found that most laboratory-confirmed cases were acquired locally, including in gardens and suburban green spaces [8].
2. Attachment time. The 24 to 48 hour window reflects the biology of bacterial migration. Brief attachment lowers risk substantially.
3. Tick life stage. Small nymphs are easy to overlook and can feed unnoticed, which is a common reason people never recall a bite [8].
Understanding these factors helps you interpret your own situation, but it does not let you rule out Lyme disease on your own. If a rash appears and you live in or have traveled to an endemic area, that combination is enough to prompt a medical visit [5].
## What Else Causes a Ring or Red Patch? The Differential
A bullseye rash is not the only red lesion that expands or forms a ring. Several common conditions imitate it, and some of them are emergencies. False positives matter because unnecessary worry drives unnecessary testing, and false negatives matter because delayed treatment of Lyme disease carries real risk.
### Ringworm
Ringworm, or tinea corporis, is a fungal skin infection that forms a ring with a scaly, raised edge and clearer center. It itches and often spreads slowly. The key differences from erythema migrans are the scaly surface and the itch. Ringworm does not follow a tick bite, though a person can develop ringworm after any outdoor exposure. Diagnosis is usually clinical and treatment is antifungal, a different path from Lyme disease.
### Cellulitis
Cellulitis is a bacterial infection of deeper skin. It presents as spreading redness, warmth, swelling, and pain, often with fever. It usually follows a break in the skin rather than a tick bite. Cellulitis is a medical urgency and can progress quickly. A red, hot, tender leg that is spreading over hours is a reason to seek same-day care.
### Spider bite
Spider bites vary widely. Many cause a red bump or blister, sometimes with a dark center, and most are painful rather than itchy. Some spider bites, including those from certain species, can cause tissue breakdown, and systemic symptoms are possible. A painful lesion with a central blister that appears within hours of a bite fits this pattern better than Lyme disease.
### Allergic reaction
Local allergic reactions to bites and stings produce raised, itchy welts within minutes. Hives can migrate around the body and resolve within a day. A new bite can trigger another round. This rapid onset and rapid resolution separates allergy from the gradual expansion of erythema migrans. A reaction with swelling of the lips, tongue, or throat, or with trouble breathing, is a medical emergency.
### When more than one explanation fits
Overlap is common. Someone with eczema, a recent sunburn, or a known fungal infection can still be bitten by a tick. The timeline does most of the sorting. Ask three questions. Did a tick bite happen, or could it have happened? When did the rash appear relative to that exposure? Is it growing, and how fast? Bring those answers to your clinician.
## Diagnosing Lyme Disease: What a Clinician Does
Diagnosis of early Lyme disease begins with the history and skin exam. Guidelines summarized in a Canadian review state that early recognition is primarily clinical, based on the characteristic erythema migrans rash and exposure to endemic areas [5]. The presence of a clear expanding rash may make laboratory testing unnecessary at the first visit.
When the rash is absent, atypical, or the picture is mixed, serologic testing becomes the main tool. Standard two-tiered testing has been the long-standing approach, and several reference laboratories have shifted to modified two-tiered testing with better early sensitivity and faster turnaround [5]. Newer single-step immunoblot assays using recombinant proteins from multiple Borrelia species and strains have shown higher sensitivity than older two-tiered methods for early-stage samples in head-to-head comparisons [14]. Comparative evaluations of testing algorithms using samples from well-characterized early Lyme patients confirm that algorithm choice affects sensitivity, and that early draws remain the weakest link [12].
Two practical points for patients and families.
1. A negative early test does not rule out Lyme disease. Early sensitivity is limited, and clinicians may treat based on the rash and exposure history [12].
2. Communication about skin findings matters. A person with darker skin should describe the rash in words, including color, size, and change over time, and mention the tick exposure explicitly. Awareness of how erythema migrans appears across skin tones remains uneven among clinicians, and patients have reported delays tied to that gap [9].
Older laboratory tests and nonstandard panels sold directly to consumers add confusion. A review of diagnostic approaches in Canada flagged nonstandardized, non-guideline-based tests from private laboratories as a source of complexity [5]. Ask your clinician which test is being used and why.
## Expanded and Later Presentations: Why Early Treatment Matters
Erythema migrans marks early, localized infection. Without treatment, Borrelia can spread. A European prospective study found that among 797 Lyme cases, 77.2 percent presented with erythema migrans and 22.8 percent had disseminated disease, including Lyme arthritis, neuroborreliosis, and Lyme carditis [15]. Proportions varied widely by country [15].
### Lyme carditis
Lyme carditis affects the heart's electrical system. A case report describes a twenty-year-old who arrived at the hospital after fainting, with a heart rate of 30 beats per minute and a third-degree atrioventricular block on electrocardiogram [7]. The history included a tick bite and migrating erythema at the bite site one month earlier, and serology was positive for Borrelia burgdorferi. The patient required a temporary external pacemaker, then a permanent two-chamber pacemaker, and eventually recovered without recurrent block [7]. This is the reason a rash plus palpitations, fainting, chest pain, or a slow or irregular pulse is a reason for emergency evaluation.
### Neuroborreliosis
Borrelia can affect the nervous system, a condition called Lyme neuroborreliosis that may involve both peripheral and central nerves [3]. A Japanese surveillance study noted that nonspecific symptoms including neurological involvement contributed to delayed diagnoses [13]. A case report from a non-endemic region of China described a man with months of relapsing fever, delirium, and septic shock, with cerebrospinal fluid showing lymphocytic pleocytosis and elevated protein [11].
### Lyme arthritis
Joint involvement is the most common disseminated form in the European data set [15]. An expanding rash that was ignored weeks earlier is a common thread in these presentations, which is why early evaluation of a bullseye rash pays off.
## How Lyme Disease in Dogs Differs: A Short Veterinary Comparison
Dogs can be infected with Borrelia burgdorferi through the same Ixodes ticks that bite people. The veterinary picture differs in a few important ways.
- Dogs rarely develop erythema migrans. The expanding bullseye rash is a human hallmark and does not appear reliably in dogs, so owners and veterinarians cannot use it to screen for infection [1].
- Clinical signs in dogs are often joint-centered. Lameness that shifts between legs, reluctance to move, and lethargy are the most common reasons a dog gets evaluated for Lyme disease. The causative organism and the tick vector are shared with people, but the clinical emphasis is on the joints and general malaise rather than the skin [1].
- Testing is serologic. Veterinary diagnosis relies on antibody testing, and a positive result indicates exposure. Many exposed dogs never develop clinical illness, so the veterinarian's job is to determine whether the positive test explains the current problem. Your veterinarian can interpret the result in the context of your dog's exam, history, and tick exposure.
- Prevention is the same story. Daily tick checks, prompt removal of any attached tick, and products prescribed by your veterinarian reduce risk. Discussion of vaccination status and tick control belongs with your veterinarian, because the appropriate plan depends on where you live and your dog's activities.
The practical consequence is this. Lyme disease in a dog is usually identified through lameness and other systemic signs plus a positive antibody test, not through a rash. If you have a bullseye rash, you are dealing with a human medical issue.
## Management: What to Expect After a Diagnosis
Early Lyme disease is treated with antibiotics prescribed by a clinician. Treatment decisions, drug choice, dose, and duration are medical decisions made in the context of your symptoms, allergies, pregnancy status, and any heart or nervous system involvement. Do not take antibiotics left over from a previous illness, and do not borrow or share prescriptions, because the wrong drug or the wrong duration can fail to clear the infection and complicate later diagnosis.
Patients should expect a few components of care.
- Clinical diagnosis without serology at the first visit. When a characteristic rash is present in a person from an endemic area, testing may be deferred and treatment started based on the exam [5].
- Recheck and symptom monitoring. Ask your clinician what to watch for and when to return. Seeking care promptly for fainting, palpitations, worsening headache, neck stiffness, or new joint swelling is important even while on antibiotics.
- Awareness that symptoms can outlast the rash. Residual fatigue and aching can occur. Discuss persistent or recurring symptoms with your clinician rather than self-treating.
For disseminated disease, care is more involved. The young man in the cardiac case report needed a temporary pacemaker, then a permanent device, before eventually recovering normal heart rhythm and stopping ventricular pacing at follow-up [7]. That outcome depended on prompt medical care for fainting.
## Home Care and Remedies That Are Unsafe
Home remedies for a suspected Lyme rash can delay effective treatment. Some specific practices to avoid.
1. Do not squeeze, cut, or apply heat to the rash. This does not remove Borrelia and can introduce a wound infection.
2. Do not apply antibiotic ointments as a substitute for systemic evaluation. Topical treatment does not address a systemic infection.
3. Do not rely on internet quizzes or symptom-checker apps to rule out Lyme disease. A study of AI-based symptom checkers with Lyme disease as a use case explored how these tools compare with clinical and serologic diagnosis and found limits in their diagnostic utility for this complex disease [6].
4. Do not buy unregulated tests or treatments online. A Canadian review specifically warned about nonstandardized, non-guideline-based tests from private, for-profit laboratories [5].
5. Do not wait and see. A bullseye rash can fade on its own while the infection continues, and disseminated disease can appear weeks later [7][15].
For pets, do not give human medications without veterinary direction, and do not remove an attached tick by crushing it against the skin. Your veterinarian can advise on safe tick removal and any follow-up testing.
## Prevention: Reducing Tick Exposure and Checking Skin and Pets
Prevention is mostly about avoiding prolonged attachment.
- Check skin and clothing after outdoor activity. Focus on skin folds, the hairline, behind the knees, the groin, and the waistband.
- Check pets too. A tick that rides into the house on a dog can move to a person. A surveillance study in England found that many recalled bites occurred at home or in gardens, not just in wild areas [8]. Prevention advice in that study emphasized tick checks and awareness that ticks occur in parks and gardens, including efforts to increase biodiversity in local green spaces [8].
- Remove attached ticks correctly. Grasp the tick close to the skin with fine-tipped tweezers and pull steadily upward. Do not twist or crush the tick. Clean the bite area after removal. Saving the tick in a sealed container with the date is useful if you develop symptoms.
- Note the date of any bite or removal. The 3 to 30 day window after a bite gives clinicians a timeline to work with [4].
- Discuss prevention with your veterinarian for pets. Tick control products and vaccination decisions are individual and belong in a conversation with your veterinarian.
## Emergency Red Flags: When to Seek Care Immediately
Call emergency services or go to an emergency department for any of the following.
- Fainting, near-fainting, palpitations, chest pain, or a pulse that feels unusually slow or irregular [7].
- Shortness of breath, facial or throat swelling, or a widespread rash with hives after a bite or sting.
- Fever with confusion, severe headache, neck stiffness, or new weakness or numbness [11][3].
- A red, hot, rapidly spreading area of skin with fever or chills.
- Worsening joint swelling with inability to bear weight.
These findings can point to cardiac, neurologic, or other serious complications that need immediate evaluation.
## Limitations and When to Contact a Veterinarian
This article focuses on the human bullseye rash and provides only a brief veterinary comparison. Individual cases vary, and neither this article nor any photograph can determine whether a specific rash is Lyme disease. For your own skin symptoms, contact a physician or urgent care clinician promptly. For your pet, contact your veterinarian if your dog develops shifting lameness, reluctance to move, lethargy, fever, or joint swelling, or if you find an attached tick and are unsure about removal. A veterinarian can examine the dog, interpret antibody testing in context, and recommend a treatment plan. If you are unsure whether a symptom is urgent for your pet, call your veterinary clinic and describe what you see. Do not wait for a rash to appear in a dog, because the characteristic rash of human Lyme disease does not reliably occur in dogs.
## Frequently Asked Questions
### How soon after a tick bite does a bullseye rash appear?
Erythema migrans typically appears 3 to 30 days after the bite [4]. A red mark that forms within minutes to hours of a bite is usually a local reaction, not Lyme disease. Timing is one of the strongest clues, so note the date of the bite or removal.
### Do all Lyme disease rashes look like a bullseye?
No. The classic central clearing pattern is common but not universal. Many Lyme rashes are solid red or pink patches that simply expand over days [4]. A growing rash after a likely tick exposure deserves the same attention as a perfect target lesion [5].
### How long does a tick need to be attached to transmit Lyme disease?
The commonly cited window is 24 to 48 hours of attachment. Borrelia bacteria migrate from the tick's gut to the salivary glands during feeding, which takes time. Removing a tick within hours lowers the chance of transmission.
### Can I have Lyme disease without ever seeing a tick or a rash?
Yes. A surveillance study of laboratory-confirmed cases found that many people did not realize they had been bitten [8]. Nymphs are small and easily missed. If you have symptoms and a plausible exposure, tell your clinician about your outdoor activities and any pets that share your home.
### Is a bullseye rash always Lyme disease?
No. Ringworm, cellulitis, spider bites, and allergic reactions can look similar. Ringworm tends to be scaly and itchy, cellulitis is hot and painful, spider bites often blister, and allergic reactions appear and fade rapidly. A clinician can usually sort these apart by examining the lesion and asking about timing.
### Why is the rash harder to see on darker skin?
Erythema migrans redness is subtler against darker skin tones, and research with people of color found that diagnostic delays were attributed in part to this reduced visibility [9]. Medical teaching images have historically underrepresented dark skin, which contributes to the problem [10]. Mentioning any tick exposure explicitly can help your clinician factor it into the assessment.
### Should I take antibiotics if I think I have a bullseye rash?
Do not self-treat. Antibiotics for Lyme disease are prescribed by a clinician after an evaluation. Drug choice and duration depend on your symptoms and medical history. Using leftover or borrowed antibiotics can fail to clear the infection and complicate diagnosis.
### Can dogs get the same bullseye rash?
Dogs can be infected with Borrelia burgdorferi, but they rarely develop erythema migrans. Lyme disease in dogs usually shows up as shifting lameness, lethargy, or joint swelling, with diagnosis based on examination and antibody testing. Because the rash is not a reliable sign in dogs, contact your veterinarian if your dog shows lameness or you find an attached tick.
## Related Articles
- [Tick-Transmitted Diseases in Dogs: Anaplasmosis, Ehrlichiosis, and Lyme Disease](/knowledge/parasites/pet-parasites/tick-transmitted-diseases-dogs-anaplasmosis-ehrlichiosis-lyme)
- [Tick-Transmitted Diseases in Dogs: Lyme Disease, Ehrlichiosis, Anaplasmosis, and Babesiosis](/knowledge/parasites/pet-parasites/tick-transmitted-diseases-dogs-lyme-ehrlichiosis-anaplasmosis-babesiosis)
- [Tick-Borne Diseases in Dogs: Lyme Disease, Ehrlichiosis, Anaplasmosis, and Babesiosis](/knowledge/parasites/pet-parasites/tick-borne-diseases-in-dogs)
- [Dog Tick-Borne Illness Treatment: A Comprehensive Guide to Ehrlichiosis, Anaplasmosis, and Lyme Disease](/knowledge/parasites/pet-parasites/dog-tick-borne-illness-treatment)
- [Canine Tick-Borne Diseases: Lyme Disease, Ehrlichiosis, Anaplasmosis, and Babesiosis](/knowledge/parasites/pet-parasites/canine-tick-borne-diseases-lyme-ehrlichiosis-anaplasmosis-babesiosis)
- [Lyme Disease In Dogs](/knowledge/veterinary-medicine/clinical-methods/lyme-disease-in-dogs)
- [Epizootic Hemorrhagic Disease in Deer: Signs and Spread](/knowledge/veterinary-medicine/parasitic-diseases/epizootic-hemorrhagic-disease-in-deer-signs-and-spread)
## Sources
1. [Current practices in the diagnosis of Lyme disease.](https://pubmed.ncbi.nlm.nih.gov/42105311/)
2. [Single-cell immunophenotyping identifies CD8+GZMK+IFNG+ T cells as a key immune population in cutaneous Lyme disease.](https://pubmed.ncbi.nlm.nih.gov/41729083/)
3. [[Lyme Disease: Spirochaetota].](https://pubmed.ncbi.nlm.nih.gov/42156055/)
4. [Lyme Disease: More Than a Bullseye Rash.](https://pubmed.ncbi.nlm.nih.gov/41511767/)
5. [Update on Lyme disease diagnostic approaches and protocols in Canada: Overview of existing testing strategies and limitations.](https://pubmed.ncbi.nlm.nih.gov/42527336/)
6. [AI-Based Diagnostic Platform Capabilities With Lyme Disease as a Use Case: Integrative Exploration.](https://pubmed.ncbi.nlm.nih.gov/42441703/)
7. [Association of Lyme Disease and Erythema Migrans with Atrioventricular Block.](https://pubmed.ncbi.nlm.nih.gov/41178656/)
8. [Results from an enhanced surveillance study of laboratory-confirmed acute Lyme disease cases in England between 1 April 2023 and 31 March 2024.](https://pubmed.ncbi.nlm.nih.gov/42294764/)
9. [Perspectives on Lyme disease among persons of color in the United States: Qualitative research findings.](https://pubmed.ncbi.nlm.nih.gov/42730232/)
10. [Skin Tone Representation of Early Lyme Disease in Medical Education Resources: Gaps and Implications for Equity.](https://pubmed.ncbi.nlm.nih.gov/41551939/)
11. [A rare presentation of clinically diagnosed lyme disease with probable neuroborreliosis, septic shock, and bone marrow suppression: a case report.](https://pubmed.ncbi.nlm.nih.gov/42436393/)
12. [Evaluation of standard and modified two-tiered testing algorithms using well-characterized early Lyme disease samples.](https://pubmed.ncbi.nlm.nih.gov/42012197/)
13. [Epidemiology of Lyme disease, a growing tick-borne disease of concern, in Japan from May 2013 to March 2024: a descriptive study.](https://pubmed.ncbi.nlm.nih.gov/42317500/)
14. [Single-step immunoblot tests with recombinant protein antigens for detecting IgG and IgM antibodies in Lyme disease.](https://pubmed.ncbi.nlm.nih.gov/42455001/)
15. [Clinical Manifestations of Lyme Borreliosis in Europe: Burden of Lyme Disease Study (BOLD), 2021-2022.](https://pubmed.ncbi.nlm.nih.gov/41901780/)
