# Rat Grooming Guide: Coat, Nails, and Skin Checks

Rats groom themselves constantly and thoroughly. In a healthy pet rat, self-grooming is one of the most frequent behaviors you will see, and research on enriched rats shows that normal animals actually groom more, not less, when their environment and stress levels are good [1]. Your job as an owner is not to replace that grooming. Your job is to support it, observe it, and step in for the three things a rat cannot do alone: nail trims, skin checks in places the rat cannot see well, and intervention when grooming stops or turns excessive.

A practical rat grooming routine has four parts. Check the coat and skin over the whole body once a week. Check and trim nails when the tips start to catch or curl. Bathe rarely, only when a rat is genuinely soiled. And treat every grooming session as a head-to-tail health check, because the coat and skin are often the first places illness and stress show up.

This article is educational and is not a substitute for veterinary diagnosis or treatment.

## Rat Grooming at a Glance

| Task | How often | What you are checking | Act now if |
|--|--|--|--|
| Quick visual check | Every day, in passing | Activity level, posture, coat sitting normally | Rat is hunched, fluffed up, or hiding |
| Hands-on skin and coat check | Weekly | Bald patches, scabs, wounds, lumps, red staining around eyes or nose, nail length | New scabs, spreading hair loss, or staining that does not resolve |
| Nail check | Every few weeks to every couple of months, depending on activity and surfaces | Nails catching on fabric, curling tips, overgrown hind nails | Nail is broken, bleeding, or the rat is limping |
| Bath | Rarely, only when soiled or advised by a veterinarian | Soiled rear, sticky substrate, residue on the coat | Skin looks inflamed after bathing |
| Full weigh-in and exam | Monthly, plus whenever something looks off | Body weight trend, body condition, teeth and face on visual inspection | Weight is dropping, or the rat resists handling that it previously tolerated |
| Veterinary visit | As needed | Anything abnormal that persists more than a day or two | Bleeding, breathing changes, sudden behavior change, suspected pain |

## Why Grooming Matters More Than It Looks

Formal welfare assessment in rats relies heavily on the same things you check at home. Published assessment frameworks score body weight, general appearance, and spontaneous behavior as core welfare parameters [2], and general assessment methods for rat welfare treat coat condition and appearance as baseline health indicators [3]. When a rat stops maintaining its coat, that change carries information.

There is a catch, and it matters for owners. A study comparing standard visual score sheets against fecal corticosterone metabolites, an objective measure of adrenal stress activity, found that specific subjective appearance scores did not reliably mirror the animal's actual stress response [4]. In plain terms, a rat can look fine and not be fine. Visual checking is where grooming routines start, not where they end. Pair what you see with weight trends, behavior, and veterinary exams.

Grooming behavior itself is also a stress barometer. In a controlled study, rats that experienced routine husbandry procedures during their normal sleeping period showed significantly more chromodacryorrhoea, the reddish porphyrin discharge around the eyes and nose, along with less sleep, less self-grooming, and less engagement with enrichment compared with rats handled during their active period [5]. Two practical lessons follow from that finding. First, red crusting around the eyes or nose is a signal to look for, not a cosmetic problem. Second, the timing of your grooming and cage-cleaning sessions matters, and doing them during the rat's active hours reduces a measurable stress burden.

## How Often to Groom a Rat

If you are looking for a single answer to how often to groom a rat, here is the baseline routine that works for most pet households:

1. Daily, a ten-second visual check while the rat is awake and moving. You are confirming normal posture, normal breathing, and a coat that sits smoothly.
2. Weekly, a hands-on check. Run your fingers over the whole body, part the fur in a few spots, look at the belly, the rear end, the base of the tail, the ears, and between the shoulder blades.
3. Every few weeks to every couple of months, check nail length. The right interval depends on the individual. Active rats with access to climbing surfaces and rough textures often wear their nails down and need trims rarely. Older or less mobile rats often need trims more often.
4. Monthly, a full hands-on exam plus a weigh-in on a small digital scale. Body weight is one of the most useful numbers you can track, and it is a core parameter in formal rat welfare scoring [2].
5. Baths, rarely. Most rats go their whole lives needing only occasional spot cleaning.

Two factors shift this schedule. Age is the big one. A large survey of 677 pet rat owners documented clear age-dependent changes in reported behavior [6], and older rats commonly groom themselves less effectively as arthritis and reduced flexibility set in. Expect to help older rats more with the rear end, the base of the tail, and the nails. The second factor is group composition. Rats groom each other, so a rat that has lost a cagemate, or a single-housed rat, may show changes in grooming patterns that have social roots rather than skin problems.

## Coat Care for Pet Rats

### Brushing

Most pet rats need very little coat work. Short-haired rats keep their coats in good condition through self-grooming and social grooming. A soft-bristled brush or a small grooming glove used for a minute or two during handling sessions is enough, and many rats enjoy it as a form of social contact. Brush gently in the direction of hair growth and stop if the rat shows any sign of discomfort over a particular area, because tenderness to touch is information.

Rex-coated rats have curlier, more fragile fur that can benefit from even lighter handling. Whatever the coat type, the goal of brushing is to remove loose debris and give you a structured reason to run your hands over the entire animal. The inspection matters more than the brushing.

### Bathing

Rats produce natural skin oils and generally do not need baths. A full bath is warranted only when a rat is genuinely soiled, has substrate stuck to the coat, has a soiled rear end, or when a veterinarian recommends it for a specific skin condition. When a bath is needed:

- Use a shallow basin with a few centimeters of lukewarm water, no more than needed to reach the belly.
- Use a product formulated for small animals, or ask your veterinarian to recommend one. Never use dish detergent or human shampoo as a default.
- Keep the session short and warm, and dry the rat thoroughly with a towel in a draft-free room.
- Watch for stress. If a rat panics, stop. A stressed, half-washed rat is worse off than a slightly dirty one, and there are gentler ways to handle most soiling problems, such as wiping with a damp cloth.

Frequent bathing is a common and avoidable mistake. It dries the skin, can contribute to itchiness, and turns grooming time into something the rat fears. If you find yourself bathing a rat regularly for odor or greasiness, that is a veterinary question, not a bathing-frequency question. Underlying skin disease and hormonal conditions can drive coat changes that no amount of bathing fixes.

## Skin Checks and Common Rat Skin Problems

A structured weekly skin check is the single most valuable part of rat grooming, because rat skin problems tend to announce themselves through the coat and through behavior before anything looks dramatic. Here is what to work through each week, from head to tail.

### Eyes, nose, and face

Look for porphyrin staining, which appears as red-brown crusting around the eyes or nostrils. The Abou-Ismail husbandry study identified elevated chromodacryorrhoea scores as part of a stress signature in rats whose routines were disrupted during their sleep phase [5], and it is widely used as a stress and illness indicator in welfare scoring. Occasional small amounts after sleep can be normal. Persistent or heavy staining, especially combined with lethargy or a rough coat, warrants a veterinary appointment.

Also watch the face for the signs used in the Rat Grimace Scale, a validated facial expression tool for identifying pain in rats. The scale scores changes around the eyes, ears, nose, cheeks, and whiskers, and research shows it can be applied in real time during observations to catch pain early and allow intervention [7]. You do not need clinical training to notice that a rat's ears are angled oddly, the eyes are squinted, or the nose and cheeks look tense. Those changes, especially alongside hunched posture, are a reason to call your veterinarian.

### Skin, fur, and parasites

Part the fur in several places and look at the skin itself. You are looking for scabs, redness, flaking, wounds, and any break in the skin. Hair loss and itching in rats have several possible causes, including mites, barbering by cagemates, allergies, and systemic illness. You generally cannot tell these apart at home, and treatment differs completely depending on the cause. If you find spreading hair loss, scabs, or persistent scratching, plan a veterinary visit rather than starting home remedies.

### Barbering and over-grooming

Barbering, where fur is chewed short, often in patches, is common in group-housed rats and is usually done by a cagemate. It looks distinctive because the fur is clipped short but the skin underneath looks healthy. The social environment matters here. A classic study of male rat housing found that singly housed rats showed reduced activity and a greater incidence of self-directed behaviors compared with group-housed rats, including behaviors consistent with tail manipulation as a substitute for social contact [8]. In other words, a rat without companions may redirect social and grooming behaviors onto itself. If a single-housed rat starts barbering itself, the most useful first question is not what shampoo to use but whether the rat has appropriate social contact.

### Lumps, wounds, and the rear end

Feel along the body during your weekly check. Note any lump, even a small one, and monitor whether it changes. Check the belly, the genitals, and the rear for soiling, redness, or swelling. Check the base of the tail and the tail itself for injuries and for bite wounds, which are easy to miss under fur elsewhere on the body.

### When grooming changes

The most overlooked rat skin problem is not a lesion. It is a rat that has stopped grooming. A dull, greasy, or unkempt coat in a rat that used to be immaculate is a significant red flag in welfare terms, because general appearance and spontaneous behavior are core components of structured welfare scoring in rats [2]. Unkempt coat plus reduced activity plus weight loss is a pattern that justifies a prompt veterinary visit, not a wait-and-see approach.

## How to Trim Rat Nails

Overgrown nails catch on fabric and hammocks, curl toward the pads, and can scratch both the rat and your arms during handling. Learning how to trim rat nails is one of the two hands-on skills every rat owner should have, and it is very learnable.

### Tools

- Small animal nail clippers or human infant nail clippers with a fine cutting edge.
- A styptic product to stop bleeding if you nick the quick. Ask your veterinarian which product they recommend and how to use it before your first trim.
- A small towel for optional gentle restraint.
- High-value treats for before, during, and after.
- Optional, a second person to hold and offer treats while you trim.

### Step by step

![Five steps for a calm nail trim, from working in the evening to cutting only the clear tip and giving treats.](/article-images/illustrations/rat-grooming-nail-trim-steps.webp)

1. Pick the right time. Work during the rat's active phase, typically evening for most pet rats. The evidence on husbandry timing is clear that procedures during the sleep phase increase stress markers and disrupt sleep [5], and a calm rat is a safer rat to trim.
2. Get the rat comfortable first. Handle the feet gently during ordinary cuddle sessions for several days before the first trim so paw handling is familiar.
3. Position the rat securely. Many owners hold the rat against their chest with the paw extended, or sit the rat on a towel-wrapped lap. You need a stable rat and a clear view of the nails. Do not squeeze.
4. Examine each nail before cutting. In pale nails you can often see the pink quick, the living core containing the blood vessel, running partway down the nail. In darker nails you may not see it, so trim conservatively.
5. Remove only the sharp tip. Cut just the clear, curved end of the nail, well away from where the quick begins. With dark nails, take off less than you think you need and trim again sooner.
6. Work in small sets. Two or three nails, then a treat, then continue. There is no rule that says a trim must be finished in one session. Short positive sessions build a rat that tolerates the procedure for life.
7. If a nail bleeds, apply firm gentle pressure with your styptic product or a clean cloth until bleeding stops, and keep the rat calm on a clean surface afterward.
8. Stop if the rat is panicking. Fight-or-flight rats bite, and a bad first experience makes every future trim harder. End on a treat and try again later or sooner in smaller pieces.

If your rat is too anxious for home trims, or if you have any doubt about where the quick is, ask your veterinarian to do the trim and show you their technique. Watching it done once on your own animal is worth more than any written description.

### Helping nails wear down naturally

Rats kept on smooth surfaces alone tend to need more frequent trims. Providing climbing structures, rough textures, and varied cage furniture gives nails natural wear, and rats show a clear preference for complex environments with shelters and multiple objects that allow diverse behaviors [9]. Enrichment is not a substitute for checking nails, but a physically active rat in a varied environment often needs trims less often than a sedentary one.

## Handling and Low-Stress Grooming Sessions

Everything in rat grooming goes better when the rat trusts the process, and that trust can be built deliberately.

Schedule matters first. Do grooming, cage cleaning, weighing, and trims while the rat is naturally awake. The study on husbandry timing found that procedures during the light-phase sleep period produced a measurably worse welfare profile, including more chromodacryorrhoea and less sleep, than the identical procedures performed during the active dark phase [5]. For a pet rat living in a household, that translates to a simple rule. Groom in the evening or whenever your rat is up and moving, not after it has just settled down to sleep.

Handling style matters next. Research on playful handling, the gentle hand interaction modeled on rat rough-and-tumble play, shows it reliably increases 50 kHz ultrasonic vocalizations, which are an established indicator of positive affective state in rats [10]. Female rats in that work responded best to minimal or no pinning, which is a useful reminder that individual rats differ in how much playful roughness they enjoy. Let the rat set the pace. An enrichment study using ball pits and playpens found the same positive pattern, with access to these resources increasing positive-affect vocalizations and even mitigating negative affective states induced by an anxiogenic intervention [11]. The take-home for grooming is straightforward. A rat that experiences handling sessions as play, exploration, and treat time will cooperate with nail trims and skin checks far better than one that only sees hands when something unpleasant happens.

Finally, watch for change in what the rat is willing to do. A pilot study tracking trained task performance alongside hair corticosterone and the Rat Grimace Scale found that declining task performance coincided with rising physiological stress markers and illness [12]. In a pet context, the parallel behavior is easy to read. A rat that suddenly refuses handling, stops coming to the cage door, or stops performing tricks it used to enjoy is telling you something. Grooming time is when you are most likely to notice.

## Supplies Checklist

You do not need much, and none of it requires brand loyalty:

- Small animal or infant nail clippers with a fine cutting edge.
- A styptic product for nail bleeding, selected with your veterinarian's guidance.
- A soft-bristled brush or grooming glove.
- A plain absorbent towel for restraint and drying.
- A shallow basin for the rare bath, plus a small-animal shampoo recommended by your veterinarian.
- A small digital scale that reads in grams, for monthly weigh-ins. Body weight tracking is a core welfare parameter in formal rat assessment frameworks [2].
- A travel carrier, so the trip to the veterinarian is part of the routine rather than a crisis.
- High-value treats reserved for grooming and handling sessions.
- A wheel or climbing structures and varied cage furniture, which support natural activity and give rats the complex environments they prefer [9].

## Common Mistakes

- Grooming during the rat's sleep hours. Husbandry during the sleep phase raises stress markers and disrupts sleep. Move your grooming window.
- Bathing frequently. It dries the skin and teaches the rat to fear handling. Spot clean instead, and investigate persistent grease or odor with your veterinarian.
- Cutting nails too short. The quick bleeds and hurts. Take less than you think, more often.
- Trusting appearance alone. Visual assessment scores in rats did not match objective stress measures in a controlled comparison [4]. Combine looking with weighing and hands-on checks.
- Housing a rat alone and then wondering about barbering. Single housing drives self-directed behaviors in male rats [8]. Social contact is a grooming-relevant welfare need, and larger groups in one study showed more social interaction and less emotional reactivity than pairs [13].
- Ignoring red eye staining because it looks minor. Persistent porphyrin discharge is a recognized stress and illness indicator in rats.
- Skipping weight. Monthly weigh-ins catch problems that a good-looking coat hides.
- Pushing through panic. A frightened rat learns that hands mean bad things, which undermines every future grooming session. Short, rewarded sessions win over restraint.

## Housing and Lifestyle Factors That Show Up in the Coat and Nails

Grooming outcomes depend heavily on the environment the rat lives in, and this is where the laboratory rat literature offers pet owners a lot of usable guidance.

Social housing is the foundation. Rats are a social species, and social network analyses of rat colonies show stable affiliation patterns built mainly around littermates [14]. Group housing supports natural grooming exchanges and normal behavior. A rat living alone loses those exchanges, and the behavioral consequences, including increased self-directed behavior, are documented [8].

Space and group size also matter. In a study of housing density and space allocation, dominant animals showed more optimistic judgment-bias responses than subordinates under both high-density and small-space conditions, indicating that crowding and limited space shape welfare in measurable ways [15]. Rats in larger groups in a separate study had more social interactions and showed less emotional reactivity than pair-housed rats [13]. For grooming, the practical translation is that cramped or tense social conditions show up in the coat, through barbering, wounds, and disrupted self-grooming.

Enrichment rounds it out. A systematic review of environmental enrichment in rats and mice concluded that stimulating environments are essential for the development of natural behavior and welfare, while confinement and under-stimulation have potentially detrimental effects [16]. Rats prefer complex environments with shelters and multiple resources [9], and enriched rats in one study showed increased grooming frequency alongside lower corticosterone levels [1]. An active rat with things to do grooms properly, wears its nails, and gives you a cleaner behavioral signal when something goes wrong.

## Limitations and When to Contact a Veterinarian

![Decision path from a grooming session to vet contact, branching on bleeding, breathing, pain signs and coat or weight change.](/article-images/illustrations/rat-grooming-vet-escalation.webp)

Individual cases vary, and any specific diagnosis, treatment, medication, or procedure for your rat needs a veterinarian who can examine the animal. The routine in this article is a baseline, not a medical protocol.

Contact your veterinarian promptly, meaning within a day rather than a week, if you observe any of the following:

- Bleeding that does not stop with firm pressure, whether from a nail, a wound, or the skin.
- Persistent porphyrin staining around the eyes or nose, especially with lethargy or a rough coat.
- Spreading hair loss, scabs, or relentless scratching, since causes range from parasites to systemic disease and require diagnosis.
- Any lump, particularly one that is growing or ulcerated.
- Squinted eyes, oddly angled ears, a tense muzzle, or hunched posture, the facial and postural signs associated with pain in the Rat Grimace Scale framework [7].
- Weight loss or a rat that stops eating or drinking normally.
- Breathing changes, rattling, or labored respiration.
- Sudden behavior change, including a rat that stops grooming, stops playing, or hides constantly.
- An unkempt coat in a previously well-groomed rat.
- Reluctance to move, limping, or a broken nail with swelling.

Bring your weight log and a short behavior history to the appointment. Objective numbers and observed patterns give your veterinarian more to work with than a verbal impression.

## Frequently Asked Questions

### How often to groom a rat?

Run a quick visual check daily, a hands-on skin and coat check weekly, a full exam with weigh-in monthly, and nail checks every few weeks to every couple of months depending on the individual. Baths are rare events, only when the rat is genuinely soiled.

### Do rats need baths?

Rarely, if ever. Rats keep their own coats clean through self-grooming and mutual grooming, and frequent bathing dries the skin and stresses the rat. Spot clean with a damp cloth when possible and reserve full baths for genuine soiling or a veterinarian-directed skin treatment.

### How do I trim rat nails safely?

Use small animal or infant nail clippers, work during the rat's active evening hours, and cut only the clear tip of each nail, well away from the pink quick. Have styptic powder ready, work in short rewarded sessions, and ask your veterinarian to demonstrate on your rat if you are unsure.

### Why is my rat barbering itself or its cagemates?

Barbering is common in groups and often just a cagemate chewing fur. Self-barbering in a single-housed rat, however, has documented links to isolation and increased self-directed behavior, so look first at social housing. Ask your veterinarian to rule out skin disease if the skin underneath looks abnormal.

### What is the red staining around my rat's eyes or nose?

That is porphyrin discharge, called chromodacryorrhoea, and research shows it increases when rats are stressed or unwell. A little after sleeping can be normal, but persistent or heavy staining deserves a veterinary visit.

### What are the most common rat skin problems?

Scabs and itching from mites or allergies, barbering-related hair loss, wounds from cage-mate conflict, and lumps, especially in older rats. These require different treatments, so a spreading problem should be diagnosed by a veterinarian rather than treated at home.

### Can grooming tell me if my rat is sick?

Yes, often before anything else does. An unkempt coat, a hunched posture, squinted eyes, and refusal to be handled are recognized welfare and pain indicators in rats. Also weigh monthly, because weight loss can appear while the coat still looks acceptable.

### When should I stop a grooming session and call the vet instead?

Stop immediately if the rat panics, bleeds, shows pain signs, or collapses. Call the veterinarian for any bleeding that does not stop, breathing changes, sudden lethargy, spreading skin lesions, or a rat that has stopped eating, drinking, or grooming. Those are escalation signs, not grooming problems.

<script type="application/ld+json">
{
  "@context": "https://schema.org",
  "@type": "FAQPage",
  "mainEntity": [
    {
      "@type": "Question",
      "name": "How often to groom a rat?",
      "acceptedAnswer": {
        "@type": "Answer",
        "text": "Run a quick visual check daily, a hands-on skin and coat check weekly, a full exam with weigh-in monthly, and nail checks every few weeks to every couple of months depending on the individual. Baths are rare events, only when the rat is genuinely soiled."
      }
    },
    {
      "@type": "Question",
      "name": "Do rats need baths?",
      "acceptedAnswer": {
        "@type": "Answer",
        "text": "Rarely, if ever. Rats keep their own coats clean through self-grooming and mutual grooming, and frequent bathing dries the skin and stresses the rat. Spot clean with a damp cloth when possible and reserve full baths for genuine soiling or a veterinarian-directed skin treatment."
      }
    },
    {
      "@type": "Question",
      "name": "How do I trim rat nails safely?",
      "acceptedAnswer": {
        "@type": "Answer",
        "text": "Use small animal or infant nail clippers, work during the rat's active evening hours, and cut only the clear tip of each nail, well away from the pink quick. Have styptic powder ready, work in short rewarded sessions, and ask your veterinarian to demonstrate on your rat if you are unsure."
      }
    },
    {
      "@type": "Question",
      "name": "Why is my rat barbering itself or its cagemates?",
      "acceptedAnswer": {
        "@type": "Answer",
        "text": "Barbering is common in groups and often just a cagemate chewing fur. Self-barbering in a single-housed rat, however, has documented links to isolation and increased self-directed behavior, so look first at social housing. Ask your veterinarian to rule out skin disease if the skin underneath looks abnormal."
      }
    },
    {
      "@type": "Question",
      "name": "What is the red staining around my rat's eyes or nose?",
      "acceptedAnswer": {
        "@type": "Answer",
        "text": "That is porphyrin discharge, called chromodacryorrhoea, and research shows it increases when rats are stressed or unwell. A little after sleeping can be normal, but persistent or heavy staining deserves a veterinary visit."
      }
    },
    {
      "@type": "Question",
      "name": "What are the most common rat skin problems?",
      "acceptedAnswer": {
        "@type": "Answer",
        "text": "Scabs and itching from mites or allergies, barbering-related hair loss, wounds from cage-mate conflict, and lumps, especially in older rats. These require different treatments, so a spreading problem should be diagnosed by a veterinarian rather than treated at home."
      }
    },
    {
      "@type": "Question",
      "name": "Can grooming tell me if my rat is sick?",
      "acceptedAnswer": {
        "@type": "Answer",
        "text": "Yes, often before anything else does. An unkempt coat, a hunched posture, squinted eyes, and refusal to be handled are recognized welfare and pain indicators in rats. Also weigh monthly, because weight loss can appear while the coat still looks acceptable."
      }
    },
    {
      "@type": "Question",
      "name": "When should I stop a grooming session and call the vet instead?",
      "acceptedAnswer": {
        "@type": "Answer",
        "text": "Stop immediately if the rat panics, bleeds, shows pain signs, or collapses. Call the veterinarian for any bleeding that does not stop, breathing changes, sudden lethargy, spreading skin lesions, or a rat that has stopped eating, drinking, or grooming. Those are escalation signs, not grooming problems."
      }
    }
  ]
}
</script>

## Sources

1. [Effect of prenatal and postnatal environmental enrichment on laboratory rats' welfare](https://doi.org/10.21608/jvmr.2016.43213)
2. [Animal welfare assessment after severe traumatic brain injury in rats](https://pubmed.ncbi.nlm.nih.gov/35942536/)
3. [Methods for General Assessment of the Welfare of Laboratory Rats](https://doi.org/10.1080/090647001316923199)
4. [Additional Assessment of Fecal Corticosterone Metabolites Improves Visual Rating in the Evaluation of Stress Responses of Laboratory Rats](https://pubmed.ncbi.nlm.nih.gov/33807941/)
5. [Let sleeping rats lie: Does the timing of husbandry procedures affect laboratory rat behaviour, physiology and welfare?](https://doi.org/10.1016/J.APPLANIM.2007.06.019)
6. [Thinking outside the lab: can studies of pet rats inform pet and laboratory rat welfare?](https://doi.org/10.1016/j.applanim.2021.105507)
7. [Real-time application of the Rat Grimace Scale as a welfare refinement in laboratory rats](https://pubmed.ncbi.nlm.nih.gov/27530823/)
8. [Housing and Welfare in Laboratory Rats: Welfare Implications of Isolation and Social Contact Among Caged Males](https://doi.org/10.1017/s0962728600020042)
9. [A mapping review of refinements to laboratory rat housing and husbandry](https://pubmed.ncbi.nlm.nih.gov/36759746/)
10. [Stage 2 Registered Report: Refinement of tickling protocols to improve positive animal welfare in laboratory rats](https://pubmed.ncbi.nlm.nih.gov/40963525/)
11. [The use of ball pits and playpens in laboratory Lister Hooded male rats induces ultrasonic vocalisations indicating a more positive affective state and can reduce the welfare impacts of aversive procedures](https://pubmed.ncbi.nlm.nih.gov/35023405/)
12. [Can trained behavior serve as tool for welfare assessment? A pilot study in a cancer model with Wistar rats.](https://pubmed.ncbi.nlm.nih.gov/42433085/)
13. [Effects of physical activity and group size on animal welfare in laboratory rats](https://doi.org/10.1017/s0962728600000300)
14. [The “Second Life” of laboratory rats (Rattus norvegicus): Assessment of social behavior of a colony of rats based on social network analysis](https://pubmed.ncbi.nlm.nih.gov/36217647/)
15. [Assessment of housing density, space allocation and social hierarchy of laboratory rats on behavioural measures of welfare](https://pubmed.ncbi.nlm.nih.gov/28926644/)
16. [Bored at home?-A systematic review on the effect of environmental enrichment on the welfare of laboratory rats and mice](https://pubmed.ncbi.nlm.nih.gov/36061113/)