# Heart Disease Diet Dogs: Low Sodium Taurine and L-Carnitine


## Key Takeaways

- Dietary management for canine heart disease focuses on reducing cardiac workload and supporting myocardial function, primarily through sodium restriction to mitigate fluid retention and edema.
- Taurine is a conditionally essential amino acid critical for cardiac muscle function; deficiency is definitively linked to dilated cardiomyopathy (DCM), necessitating monitoring and potential supplementation.
- L-carnitine aids in transporting fatty acids into mitochondria for energy production within heart muscle cells and is often considered as adjunctive therapy for DCM, particularly in predisposed breeds.
- Omega-3 fatty acids (EPA and DHA) demonstrate cardioprotective effects, including anti-inflammatory properties and a reduced risk of arrhythmias in dogs with myxomatous mitral valve disease (MMVD).
- The association between grain-free, legume-rich diets and DCM is under investigation, suggesting a multifactorial etiology potentially involving dietary ingredients, genetic predisposition, and other factors, rather than a singular nutrient deficiency.
- Therapeutic cardiac diets, formulated by veterinary nutritionists, are essential for precise nutrient management, and any dietary changes must be implemented under veterinary guidance to avoid counterproductive effects.

---

If your [dog](/knowledge/veterinary-medicine/clinical-methods/dog) has been diagnosed with heart disease, dietary changes are often part of the treatment plan. The primary nutritional goals for dogs with heart disease are to reduce the workload on the heart, manage fluid retention, and support cardiac muscle function. This typically involves a diet that is low in sodium, and in some cases, supplemented with specific nutrients like taurine and L-carnitine. However, the right diet depends on the type and stage of heart disease, and it must be chosen in consultation with your veterinarian. This article explains the evidence behind these nutritional strategies, what the latest research shows, and how to approach dietary management for a dog with a cardiac condition.

**Owner Triage Summary:** If your dog has been diagnosed with heart disease, do not change their diet without veterinary guidance. A sudden switch to a low-sodium diet, especially in a dog with advanced heart disease, can be counterproductive. Before making any changes, discuss the specific type of heart disease (e.g., myxomatous mitral valve disease or dilated cardiomyopathy), its stage, and your dog's overall health with your veterinarian. They can recommend a therapeutic diet or a balanced homemade diet formulated by a veterinary nutritionist. Watch for emergency red flags like difficulty breathing, a bluish tongue, or collapse, and seek immediate veterinary care if these occur.

## Understanding the Role of Nutrition in Canine Heart Disease

The heart is a high-energy organ that relies on a constant supply of nutrients and oxygen. In heart disease, the heart's efficiency drops, and it may struggle to meet the body's demands. Nutrition plays a supportive role in managing this condition. The goals of dietary therapy are to:

1.  **Minimize fluid accumulation (edema and ascites):** This is primarily achieved by controlling sodium intake.
2.  **Support myocardial energy metabolism:** Nutrients like taurine and L-carnitine are involved in energy production within heart muscle cells.
3.  **Reduce oxidative stress:** Antioxidants can help protect heart tissue from damage.
4.  **Manage body weight:** Obesity can worsen heart disease, so maintaining a healthy weight is crucial.

The most common forms of heart disease in dogs are myxomatous mitral valve disease (MMVD) and dilated cardiomyopathy (DCM). Each has different underlying causes and may respond differently to nutritional interventions.

### Myxomatous Mitral Valve Disease (MMVD)

MMVD is the most common acquired heart disease in dogs, particularly in small breeds like Cavalier King Charles Spaniels. It involves a progressive thickening and degeneration of the mitral valve, leading to a leaky valve and eventually heart enlargement [<a href="#ref-1">1</a>]. Research has shown that dogs with MMVD have altered myocardial energy metabolism, which has led to interest in diets that can support cardiac energy production [<a href="#ref-1">1</a>].

### Dilated Cardiomyopathy (DCM)

DCM is a disease of the heart muscle itself, where the chambers enlarge and the muscle weakens, leading to poor pumping function. While DCM has a genetic component, especially in large breeds, it has also been associated with diet, particularly grain-free and legume-rich diets [<a href="#ref-2">2</a>]. This diet-associated DCM has received significant attention, and research is ongoing to understand the mechanisms involved [<a href="#ref-3">3</a>][<a href="#ref-2">2</a>][<a href="#ref-4">4</a>].

## The Three Pillars of a Heart-Healthy Diet

When veterinarians discuss a heart disease diet for dogs, they typically focus on three key areas: sodium restriction, taurine, and L-carnitine.

### 1. Low Sodium: The Foundation of Cardiac Diets

The most well-established dietary modification for heart disease is sodium restriction. High sodium intake leads to fluid retention, which increases blood volume and makes the heart work harder. This can exacerbate the signs of heart failure, such as coughing, difficulty breathing, and fluid accumulation in the abdomen.

A low-sodium diet is a cornerstone of managing heart disease, but the degree of restriction depends on the stage of the disease. For dogs in the early stages (e.g., Stage B1, where there is a heart murmur but no heart enlargement), a moderate sodium restriction may be recommended. For dogs with heart enlargement (Stage B2) or heart failure (Stage C or D), a more aggressive sodium restriction is necessary.

It is important to note that sodium restriction is not just about removing the salt shaker. It involves feeding a diet specifically formulated to be low in sodium. Many commercial "senior" or "light" diets are not low enough in sodium for dogs with significant heart disease. Therapeutic cardiac diets are formulated with precise sodium levels and other beneficial nutrients.

**Important Consideration:** In some cases, a low-sodium diet is used in research to activate the renin-angiotensin-aldosterone system (RAAS), a hormonal pathway that regulates blood pressure and fluid balance. This is done to study the effects of cardiac medications [<a href="#ref-5">5</a>][<a href="#ref-6">6</a>]. In a clinical setting, the goal is to use diet and medication together to manage this system effectively.

### 2. Taurine: An Essential Amino Acid for Heart Function

Taurine is a conditionally essential amino acid in dogs. This means that under normal conditions, a dog can synthesize enough taurine from other amino acids, but in certain situations, the demand may exceed the supply. Taurine is critical for normal heart muscle function, and a deficiency has been definitively linked to DCM.

Research has shown that low blood taurine concentrations can be present in dogs with heart disease. A 2024 study in English Cocker Spaniels found that 29% of the dogs studied had low blood taurine concentrations, and 25% of those dogs had clinical signs of congestive heart failure [<a href="#ref-7">7</a>]. The study also found that dietary methionine concentration and the source of animal protein were associated with blood taurine levels [<a href="#ref-7">7</a>]. This highlights the importance of not only taurine itself but also its dietary precursors, methionine and cysteine.

However, the relationship between diet and taurine is complex. A study in Cavalier King Charles Spaniels found no significant difference in taurine concentrations between dogs eating diets that met WSAVA guidelines and those that did not [<a href="#ref-8">8</a>]. This suggests that taurine deficiency is not solely a matter of diet quality but may involve other factors like breed-specific metabolism.

The FDA's investigation into diet-associated DCM has brought taurine into the spotlight. Some dogs with DCM eating grain-free, legume-rich diets have been found to have low taurine levels, while others have normal levels [<a href="#ref-2">2</a>]. This suggests that the link between diet and DCM is not solely explained by taurine deficiency. A 2025 study found that dogs with DCM eating high-pulse diets had higher levels of a urine biomarker for phospholipidosis, a condition involving abnormal lipid accumulation in cells, which suggests a different mechanism may be at play [<a href="#ref-4">4</a>]. This indicates that diet-associated DCM may involve more than just a simple taurine deficiency.

### 3. L-Carnitine: A Nutrient for Myocardial Energy

L-carnitine is a nutrient that plays a vital role in energy metabolism. It helps transport fatty acids into the mitochondria, the energy-producing structures within cells, where they are burned for fuel. The heart muscle relies heavily on fatty acids for energy, so adequate L-carnitine is essential for normal cardiac function.

While L-carnitine deficiency is rare in dogs, supplementation is sometimes recommended for dogs with DCM, particularly in breeds with a known predisposition to carnitine deficiency. However, the evidence for its effectiveness is not as strong as for taurine. It is often used as an adjunctive therapy alongside standard cardiac medications and taurine supplementation.

## What the Latest Research Says About Cardiac Diets

The field of veterinary cardiology and nutrition is constantly evolving. Recent studies have provided valuable insights into what works and what does not for dogs with heart disease.

### The Role of Omega-3 Fatty Acids

Omega-3 fatty acids, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been studied for their anti-inflammatory and cardioprotective effects. A 2021 study in dogs with MMVD found that omega-3 supplementation reduced the risk of developing arrhythmias by 2.96 times and helped keep dogs in milder stages of the disease [<a href="#ref-9">9</a>]. Another study found that a diet enriched with EPA and DHA from fish meat did not cause significant clinical changes but did alter the dogs' metabolomic profile over time [<a href="#ref-10">10</a>]. This suggests that omega-3s may have subtle beneficial effects on metabolism that are not immediately apparent in standard clinical tests.

A 2024 study found that a diet with higher DHA and EPA content decreased plasmatic triglycerides and the activity of angiotensin-converting enzyme (ACE), an enzyme that constricts blood vessels [<a href="#ref-11">11</a>]. This suggests a potential role for omega-3s in supporting cardiovascular health, although the clinical significance of these changes requires further investigation.

### The Grain-Free and Pulse Debate

The potential link between grain-free, legume-rich diets and DCM has been a major topic of research. The FDA has investigated this association, and many studies have been conducted to understand the cause.

- **A 2021 foodomics study** analyzed diets associated with DCM and found that they had higher concentrations of certain amino acids, amino acid-derived compounds, and plant compounds compared to non-associated diets [<a href="#ref-12">12</a>]. Peas were identified as an ingredient with the greatest association with these compounds [<a href="#ref-12">12</a>].
- **A 2025 study** found that a diet with 45% whole pulse ingredients did not affect cardiac function or sulfur amino acid status in healthy adult dogs over 20 weeks [<a href="#ref-13">13</a>]. This suggests that moderate pulse inclusion may not be inherently harmful.
- **A 2023 study** in cats found no differences in cardiac measurements or taurine concentrations between cats eating high-pulse and low-pulse diets [<a href="#ref-14">14</a>].
- **A 2025 study** in healthy dogs found that different carbohydrate sources, including grain-free options with peas and potatoes, did not cause clinically significant changes in cardiac function over 18 months [<a href="#ref-3">3</a>].

These studies paint a complex picture. While some diets have been associated with DCM, they do not cause the disease in all dogs. The cause of diet-associated DCM is likely multifactorial, involving a combination of dietary ingredients, genetic predisposition, and perhaps other environmental factors. A 2022 study found that dogs with DCM and congestive heart failure that were previously fed a grain-free diet showed greater improvement in heart size if they were switched to a different diet as part of their therapy [<a href="#ref-2">2</a>]. This suggests that diet change can be beneficial in some cases.

### The Promise of Specialized Diets

Researchers are also investigating whether specific diets can slow the progression of heart disease. A 2023 study evaluated a specially formulated diet rich in medium-chain fatty acids and antioxidants in dogs with subclinical MMVD. While the study did not find a significant difference in the primary outcome (a measure of heart enlargement) between the test and control diets, it did suggest that the diet may have some benefit in slowing the progression of heart enlargement [<a href="#ref-1">1</a>]. This is an area of active research.

## At a Glance: Comparing Nutritional Strategies

| Nutrient/Strategy | Primary Function | Evidence in Canine Heart Disease | Typical Use |
| :--- | :--- | :--- | :--- |
| **Low Sodium** | Reduces fluid retention and blood volume | **Strong.** Well-established as a cornerstone of heart failure management. | Recommended for dogs with heart enlargement or heart failure. |
| **Taurine** | Supports heart muscle function and energy metabolism | **Moderate to Strong.** Deficiency is linked to DCM. Supplementation can be life-saving in deficient dogs. | Recommended for dogs with DCM or low blood taurine levels. |
| **L-Carnitine** | Helps transport fatty acids for energy production in heart muscle | **Moderate.** May be beneficial in some dogs with DCM, but evidence is less robust than for taurine. | Often used in DCM, especially in breeds predisposed to carnitine deficiency. |
| **Omega-3 Fatty Acids (EPA/DHA)** | Anti-inflammatory, anti-arrhythmic, and may support heart function | **Moderate.** Can reduce arrhythmias and may have beneficial metabolic effects. | Often recommended as a supplement for dogs with heart disease. |
| **Medium-Chain Fatty Acids (MCFAs)** | Alternative energy source for the heart | **Emerging.** May help slow heart enlargement, but more research is needed. | Found in some therapeutic cardiac diets. |
| **Antioxidants** | Reduce oxidative stress and protect heart tissue | **Moderate.** Can support overall health and may reduce the risk of heart disease. | Often included in therapeutic diets or as supplements. |

## Diagnostic and Monitoring Considerations

Before recommending a specific diet, your veterinarian will perform a thorough diagnostic workup. This typically includes:

1.  **Physical Examination:** To listen for heart murmurs, arrhythmias, and assess for fluid accumulation.
2.  **Echocardiography (Ultrasound):** This is the gold standard for diagnosing heart disease. It allows the veterinarian to visualize the heart's structure and function, measure chamber sizes, and assess valve function [<a href="#ref-1">1</a>][<a href="#ref-8">8</a>][<a href="#ref-13">13</a>].
3.  **Blood Tests:** To check for biomarkers of heart disease, such as NT-proBNP and cardiac troponin I [<a href="#ref-13">13</a>]. Blood tests can also evaluate kidney and liver function, which is important because many cardiac medications affect these organs.
4.  **Taurine Levels:** If DCM is suspected, your veterinarian may recommend measuring whole blood and plasma taurine concentrations [<a href="#ref-7">7</a>][<a href="#ref-8">8</a>]. This helps determine if taurine supplementation is necessary.

Monitoring is an ongoing process. Dogs with heart disease need regular check-ups, including repeat echocardiograms and blood tests, to assess the progression of the disease and adjust treatment as needed.

## Managing a Dog with Heart Disease at Home

Dietary management is just one part of caring for a dog with heart disease. Here are some other important considerations:

- **Medication Compliance:** Give all medications exactly as prescribed. Heart medications are critical for managing the disease.
- **Weight Management:** Obesity puts extra strain on the heart. Work with your veterinarian to achieve and maintain a healthy body weight.
- **Exercise:** Regular, moderate exercise is beneficial, but avoid strenuous activity. Follow your veterinarian's recommendations.
- **Stress Reduction:** Minimize stress for your dog, as stress can exacerbate heart conditions.

## Unsafe Home Remedies and Misconceptions

It is crucial to be aware of what not to do when managing a dog with heart disease.

- **Do not add salt substitutes to your dog's food without veterinary approval.** Some salt substitutes contain potassium, which can be dangerous for dogs on certain heart medications.
- **Do not give human heart medications to your dog.** Many human medications are toxic to dogs.
- **Do not rely on unproven supplements.** While some supplements have evidence to support their use, many do not. Always consult your veterinarian before giving any supplement.
- **Do not switch to a low-sodium diet abruptly without guidance.** In some cases, a very low-sodium diet can activate the RAAS system, which can be harmful [<a href="#ref-5">5</a>][<a href="#ref-6">6</a>]. The transition should be gradual and monitored.

## Prevention and Long-Term Prognosis

Preventing heart disease is not always possible, as many forms have a genetic basis. However, maintaining a healthy lifestyle, including a balanced diet and regular exercise, can support overall cardiovascular health. For dogs with existing heart disease, the prognosis varies widely depending on the type and stage of the disease. Early diagnosis and appropriate management, including dietary changes, can significantly improve quality of life and survival time [<a href="#ref-2">2</a>].

## Limitations and When to Contact a Veterinarian

This article provides general information about dietary management for canine heart disease. It is not a substitute for professional veterinary advice. The specific dietary needs of your dog depend on many factors, including the type of heart disease, its stage, your dog's age, breed, and overall health. Breed-level information cannot predict how an individual dog will respond to a particular diet [<a href="#ref-8">8</a>][<a href="#ref-7">7</a>].

**Contact your veterinarian immediately if you notice any of the following emergency red flags:**

- Difficulty breathing or rapid breathing at rest
- Coughing, especially a soft, moist cough
- Weakness, lethargy, or collapse
- Pale or bluish gums
- A distended abdomen (which may indicate fluid accumulation)
- Loss of appetite or weight loss

These signs could indicate that your dog's heart disease is progressing or that they are developing congestive heart failure.

## Frequently Asked Questions

### What is the best diet for a dog with heart disease?
The best diet is a therapeutic cardiac diet prescribed by your veterinarian. These diets are specifically formulated to be low in sodium and contain optimal levels of nutrients like taurine, L-carnitine, and omega-3 fatty acids. The exact diet will depend on your dog's specific condition and stage of heart disease.

### Is a low-sodium diet necessary for all dogs with heart disease?
No, the degree of sodium restriction depends on the stage of the disease. Dogs with early-stage heart disease (a murmur without heart enlargement) may not need a strict low-sodium diet, while those with heart enlargement or heart failure do. Your veterinarian will guide you on the appropriate level of sodium restriction.

### What is the role of taurine in a heart disease diet for dogs?
Taurine is an amino acid essential for normal heart muscle function. A deficiency can cause dilated cardiomyopathy (DCM). Supplementation is crucial for dogs with low blood taurine levels. Some diets are also formulated to provide adequate taurine and its precursors, methionine and cysteine [<a href="#ref-7">7</a>].

### Should I add L-carnitine to my dog's diet?
L-carnitine is often used as an adjunctive therapy for DCM, as it helps heart muscle cells produce energy. However, it is not necessary for all dogs with heart disease. Your veterinarian may recommend it if they suspect a carnitine deficiency or if your dog has DCM.

### Are grain-free diets bad for dogs with heart disease?
The FDA has investigated a link between grain-free, legume-rich diets and DCM. While some dogs have developed DCM on these diets, the cause is not fully understood and is likely complex [<a href="#ref-2">2</a>][<a href="#ref-4">4</a>]. If your dog has heart disease, it is generally safer to feed a diet recommended by your veterinarian, which may or may not be grain-free.

### Can omega-3 fatty acids help my dog's heart?
Yes, omega-3 fatty acids (EPA and DHA) have been shown to have benefits for dogs with heart disease, including reducing the risk of arrhythmias and having anti-inflammatory effects [<a href="#ref-9">9</a>]. They are often included in therapeutic cardiac diets or recommended as supplements.

### How quickly will I see an improvement in my dog after changing its diet?
Dietary changes are not a quick fix. They are part of a long-term management plan. You may not see an immediate change in your dog's symptoms, but the diet works to slow the progression of the disease and support the heart over time. The most significant improvements are often seen when diet is combined with appropriate medication.

### Can I make a homemade diet for my dog with heart disease?
A homemade diet can be an option, but it must be formulated by a veterinary nutritionist to ensure it is complete, balanced, and meets your dog's specific needs. An improperly formulated homemade diet can be dangerous and worsen your dog's condition.

<details>
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<li>Pasławski R, Kurosad A, Ząbek A, et al. Effect of 6-Month Feeding with a Diet Enriched in EPA + DHA from Fish Meat on the Blood Metabolomic Profile of Dogs with Myxomatous Mitral Valve Disease. <i>Animals (Basel)</i>. 2021. https://pubmed.ncbi.nlm.nih.gov/34944135/</li>
<li>Oyama MA, Scansen BA, Boswood A, et al. Effect of a specially formulated diet on progression of heart enlargement in dogs with subclinical degenerative mitral valve disease. <i>J Vet Intern Med</i>. 2023. https://pubmed.ncbi.nlm.nih.gov/37392086/</li>
<li>Kittitunyapong P, Kwakkwai K, Prasertsri C, et al. Feeding practices, purchasing behaviors, and their association with non-communicable diseases in dogs: Insights from Thai pet owners. <i>Vet World</i>. 2025. https://pubmed.ncbi.nlm.nih.gov/41333724/</li>
<li>Morris EM, Stiers CA, Hancock LB, et al. Different carbohydrate sources in dog foods supported overall health and cardiac function: an 18-mo prospective study in healthy adult dogs. <i>J Anim Sci</i>. 2025. https://pubmed.ncbi.nlm.nih.gov/40642821/</li>
<li>Wesselowski S, Blake AB, Gordon SG, et al. Whole blood and plasma taurine reference intervals in adult Cavalier King Charles Spaniels and correlations between taurine concentration, diet and mitral valve disease. <i>J Am Vet Med Assoc</i>. 2022. https://pubmed.ncbi.nlm.nih.gov/36136933/</li>
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<li>Singh P, Banton S, Raheb S, et al. The Pulse of It: Dietary Inclusion of Up to 45% Whole Pulse Ingredients with Chicken Meal and Pea Starch in a Complete and Balanced Diet Does Not Affect Cardiac Function, Fasted Sulfur Amino Acid Status, or Other Gross Measures of Health in Adult Dogs. <i>J Nutr</i>. 2023. https://pubmed.ncbi.nlm.nih.gov/36972833/</li>
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<li>Manson E, Ward JL, Merodio M, et al. Dose-exposure-response of CARDALIS® (benazepril/spironolactone) on the classical and alternative arms of the renin-angiotensin-aldosterone system in healthy dogs. <i>J Vet Intern Med</i>. 2025. https://pubmed.ncbi.nlm.nih.gov/39601373/</li>
<li>Karp SI, Freeman LM, Rush JE, et al. Comparison of echocardiography, biomarkers and taurine concentrations in cats eating high- or low-pulse diets. <i>J Feline Med Surg</i>. 2023. https://pubmed.ncbi.nlm.nih.gov/36803067/</li>
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## Sources

<a id="ref-1"></a>[<a href="#ref-1">1</a>] [Effect of a specially formulated diet on progression of heart enlargement in dogs with subclinical degenerative mitral valve disease.](https://pubmed.ncbi.nlm.nih.gov/37392086/)

<a id="ref-2"></a>[<a href="#ref-2">2</a>] [Association of diet with clinical outcomes in dogs with dilated cardiomyopathy and congestive heart failure.](https://pubmed.ncbi.nlm.nih.gov/33741312/)

<a id="ref-3"></a>[<a href="#ref-3">3</a>] [Different carbohydrate sources in dog foods supported overall health and cardiac function: an 18-mo prospective study in healthy adult dogs.](https://pubmed.ncbi.nlm.nih.gov/40642821/)

<a id="ref-4"></a>[<a href="#ref-4">4</a>] [Dogs with diet-associated dilated cardiomyopathy have higher urine di-docosahexaenoyl (22:6)-bis(monoacylglycerol)phosphate, a biomarker of phospholipidosis.](https://pubmed.ncbi.nlm.nih.gov/39467380/)

<a id="ref-5"></a>[<a href="#ref-5">5</a>] [Dose-exposure-response of CARDALIS® (benazepril/spironolactone) on the classical and alternative arms of the renin-angiotensin-aldosterone system in healthy dogs.](https://pubmed.ncbi.nlm.nih.gov/39601373/)

<a id="ref-6"></a>[<a href="#ref-6">6</a>] [Dose-response of benazepril on biomarkers of the classical and alternative pathways of the renin-angiotensin-aldosterone system in dogs.](https://pubmed.ncbi.nlm.nih.gov/36792677/)

<a id="ref-7"></a>[<a href="#ref-7">7</a>] [The association between taurine concentrations and dog characteristics, clinical variables, and diet in English cocker spaniels: The Canine taURinE (CURE) project.](https://pubmed.ncbi.nlm.nih.gov/39136304/)

<a id="ref-8"></a>[<a href="#ref-8">8</a>] [Whole blood and plasma taurine reference intervals in adult Cavalier King Charles Spaniels and correlations between taurine concentration, diet and mitral valve disease.](https://pubmed.ncbi.nlm.nih.gov/36136933/)

<a id="ref-9"></a>[<a href="#ref-9">9</a>] [Protective effects of omega-3 fatty acids in dogs with myxomatous mitral valve disease stages B2 and C.](https://pubmed.ncbi.nlm.nih.gov/34265016/)

<a id="ref-10"></a>[<a href="#ref-10">10</a>] [Effect of 6-Month Feeding with a Diet Enriched in EPA + DHA from Fish Meat on the Blood Metabolomic Profile of Dogs with Myxomatous Mitral Valve Disease.](https://pubmed.ncbi.nlm.nih.gov/34944135/)

<a id="ref-11"></a>[<a href="#ref-11">11</a>] [Assessing functional properties of diet protein hydrolysate and oil from fish waste on canine immune parameters, cardiac biomarkers, and fecal microbiota.](https://pubmed.ncbi.nlm.nih.gov/39588199/)

<a id="ref-12"></a>[<a href="#ref-12">12</a>] [Investigation of diets associated with dilated cardiomyopathy in dogs using foodomics analysis.](https://pubmed.ncbi.nlm.nih.gov/34354102/)

<a id="ref-13"></a>[<a href="#ref-13">13</a>] [The Pulse of It: Dietary Inclusion of Up to 45% Whole Pulse Ingredients with Chicken Meal and Pea Starch in a Complete and Balanced Diet Does Not Affect Cardiac Function, Fasted Sulfur Amino Acid Status, or Other Gross Measures of Health in Adult Dogs.](https://pubmed.ncbi.nlm.nih.gov/36972833/)

<a id="ref-14"></a>[<a href="#ref-14">14</a>] [Comparison of echocardiography, biomarkers and taurine concentrations in cats eating high- or low-pulse diets.](https://pubmed.ncbi.nlm.nih.gov/36803067/)

<a id="ref-15"></a>[<a href="#ref-15">15</a>] [Feeding practices, purchasing behaviors, and their association with non-communicable diseases in dogs: Insights from Thai pet owners.](https://pubmed.ncbi.nlm.nih.gov/41333724/)

<a id="ref-16"></a>[<a href="#ref-16">16</a>] [A Novel UHPLC-MS/MS Method for the Measurement of 25-Hydroxyvitamin D3 in Canine Serum and Its Application to Healthy Dogs.](https://pubmed.ncbi.nlm.nih.gov/38200793/)

<a id="ref-17"></a>[<a href="#ref-17">17</a>] [An olive oil-derived NAE mixture (Olaliamid(®)) improves liver and cardiovascular health, and decreases meta-inflammation in naturally obese dogs: a double-blind, randomized, placebo-controlled study.](https://pubmed.ncbi.nlm.nih.gov/40764576/)

<a id="ref-18"></a>[<a href="#ref-18">18</a>] [Commercial Extruded Plant-Based Diet Lowers Circulating Levels of Trimethylamine N-Oxide (TMAO) Precursors in Healthy Dogs: A Pilot Study.](https://pubmed.ncbi.nlm.nih.gov/35873695/)

<a id="ref-19"></a>[<a href="#ref-19">19</a>] [Targeted proteomic analyses during combined angiotensin-converting enzyme inhibitor and mineralocorticoid receptor antagonist administration (CARDALIS®) in healthy dogs.](https://pubmed.ncbi.nlm.nih.gov/42330250/)

<a id="ref-20"></a>[<a href="#ref-20">20</a>] [Antioxidant Strategies for Age-Related Oxidative Damage in Dogs.](https://pubmed.ncbi.nlm.nih.gov/41150102/)

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