Q: What is the exact dose of Onsior for a cat?

The recommended dose of Onsior (robenacoxib) for cats is 1.0 to 2.4 mg/kg orally once daily, or 2 mg/kg subcutaneously as an injection. The exact dose for your cat will be calculated by your veterinarian based on their precise body weight.

Q: How long does it take for Onsior to work in cats?

Onsior is rapidly absorbed, with peak blood concentrations reached in less than one hour after oral or subcutaneous administration. You can expect to see pain relief and improved mobility within a few hours of administration.

Q: How many days can a cat take Onsior?

For surgical pain, Onsior is typically approved for a maximum of 3 days. For other conditions like musculoskeletal disorders, it may be used for 5 to 6 days. Always follow your veterinarian's instructions for the duration of treatment.

Q: Can I give my cat Onsior and other pain medications together?

Onsior is often used as part of a multimodal pain protocol that may include opioids (like methadone) and local anesthetics. However, you should never give your cat another NSAID or a corticosteroid while they are on Onsior, as this increases the risk of severe side effects.

Q: What are the common side effects of Onsior in cats?

Onsior is generally well-tolerated. The most common side effects are gastrointestinal and may include vomiting, diarrhoea, and decreased appetite. These are usually mild and transient. More serious side effects, such as kidney or liver issues, are rare but possible.

Q: Is Onsior safe for cats with kidney disease?

Onsior should be used with caution in cats with kidney disease. Because it is an NSAID, it can affect renal blood flow. Your veterinarian will assess your cat's kidney function before prescribing it and may recommend alternative pain relief options if there are concerns.

Q: Can I use Onsior for my cat's chronic arthritis pain?

Yes, robenacoxib has been shown to be effective for acute pain and inflammation associated with musculoskeletal disorders. However, for chronic conditions like arthritis, your veterinarian may discuss a long-term management plan, which could involve other therapies or a different dosing schedule.

Q: What should I do if I miss giving my cat a dose of Onsior?

If you miss a dose, give it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not give a double dose to make up for the missed one.

# Onsior Robenacoxib Feline Dose: Feline Surgical Pain Relief Protocol ## Key Takeaways - Robenacoxib (Onsior) is a selective COX-2 inhibitor NSAID indicated for feline surgical pain, administered orally at 1.0-2.4 mg/kg once daily or subcutaneously at 2 mg/kg pre-operatively. - Its high COX-2 selectivity (approximately 500:1 ratio) aims to minimize gastrointestinal and renal adverse effects by largely sparing COX-1 activity. - Pharmacokinetically, robenacoxib exhibits rapid absorption (peak plasma concentrations <1 hour) and is primarily eliminated via faeces (72-78%) and urine (22-28%), necessitating caution in cats with hepatic or renal compromise. - Treatment duration for surgical pain is typically limited to a maximum of 3 days, and Onsior is often integrated into multimodal analgesic protocols alongside opioids and local anesthetics for comprehensive pain management. - Safety studies demonstrate good tolerability even at supratherapeutic doses for up to 42 days, with no significant adverse effects on hematology, clinical chemistry, or post-mortem findings in healthy cats. - Contraindications include known hypersensitivity, and caution is advised in dehydrated, hypotensive, or cats with pre-existing gastrointestinal, renal, or hepatic disease; concurrent use with other NSAIDs or corticosteroids is contraindicated. --- **Direct Answer:** The recommended feline dose of Onsior (robenacoxib) for surgical pain is **1.0 to 2.4 mg/kg** administered orally once every 24 hours, or **2 mg/kg** administered subcutaneously before surgery. This coxib-class NSAID provides effective, short-term control of postoperative pain and inflammation with a high safety margin in healthy cats. **Owner Triage Summary:** If your [cat](/knowledge/veterinary-medicine/clinical-methods/cat) has undergone surgery, your veterinarian may prescribe Onsior tablets or give an injection. Give the medication exactly as directed, usually once daily with or without food. Do not double a dose if you miss one. Contact your vet immediately if you see vomiting, diarrhoea (diarrhea), decreased appetite, or lethargy. Never give human NSAIDs like ibuprofen or aspirin to your cat, as these are toxic. --- ## At a Glance: Onsior for Feline Surgical Pain | Feature | Details | | :--- | :--- | | **Active Ingredient** | Robenacoxib | | **Drug Class** | Non-steroidal anti-inflammatory drug (NSAID), selective COX-2 inhibitor [1] | | **Approved Feline Dose (Tablets)** | 1.0 to 2.4 mg/kg, orally, once daily [2][3] | | **Approved Feline Dose (Injection)** | 2 mg/kg, subcutaneously, once daily [4] | | **Duration of Use** | Typically limited to a maximum of 3 days for surgical pain [5] | | **Primary Use** | Control of postoperative pain and inflammation associated with orthopedic surgery, ovariohysterectomy (spay), and castration [5] | | **Key Advantage** | High selectivity for COX-2 over COX-1, potentially reducing gastrointestinal and renal side effects [1] | | **Excretion** | Mixed; primarily faecal (approximately 72-78%) with urinary excretion (22-28%) [6] | | **Onset of Action** | Rapid absorption; peak plasma concentrations reached in under 1 hour after oral or subcutaneous administration [7] | --- ## Understanding Robenacoxib (Onsior) Robenacoxib, marketed under the brand name Onsior, is a non-steroidal anti-inflammatory drug (NSAID) specifically developed for veterinary use in cats and dogs [8][9]. Its primary mechanism of action is the selective inhibition of the cyclooxygenase-2 (COX-2) enzyme. This enzyme is responsible for producing prostaglandins that mediate pain, inflammation, and fever. The clinical benefit of robenacoxib lies in its selectivity. COX-1 is a constitutive enzyme that protects the gastrointestinal lining, supports normal platelet function, and maintains renal blood flow. By preferentially inhibiting COX-2 over COX-1, robenacoxib aims to provide potent anti-inflammatory and analgesic effects while minimizing the adverse effects commonly associated with non-selective NSAIDs [1]. ### COX-2 Selectivity in Cats In feline whole blood assays, robenacoxib has demonstrated a remarkable selectivity index. The half-maximal inhibitory concentration (IC50) for COX-2 was found to be 0.058 microM, while for COX-1 it was 28.9 microM. This translates to a selectivity ratio of approximately 500:1 for COX-1 to COX-2 [1]. This high degree of selectivity means that at therapeutic doses, robenacoxib can effectively inhibit the enzymes that drive postoperative inflammation while largely sparing the protective COX-1 enzymes. ### Pharmacokinetics: How the Body Handles Onsior Understanding the pharmacokinetics of robenacoxib is crucial for effective dosing. In cats, robenacoxib is rapidly absorbed after both oral and subcutaneous administration, with maximum blood concentrations reached in less than one hour [7]. The drug is highly bound to plasma proteins, which influences its distribution. Robenacoxib is eliminated rapidly from the blood, with a short terminal half-life. However, its clinical effects can persist longer than its blood half-life because it is an acidic drug that concentrates in inflamed tissues [5]. The primary route of excretion is mixed. A pilot study using radiolabeled robenacoxib found that after oral administration, approximately 78.5% of the drug was excreted in the faeces and 21.5% in the urine. After intravenous administration, the figures were 72.5% in faeces and 27.5% in urine [6]. This dual route of excretion is an important consideration for cats with pre-existing hepatic or renal compromise. --- ## The Feline Surgical Pain Relief Protocol The goal of perioperative analgesia is to minimize pain and stress, facilitate a faster recovery, and reduce the risk of chronic pain syndromes. Onsior is a cornerstone of many feline surgical protocols due to its efficacy and safety profile. ### Preoperative vs. Postoperative Administration Onsior can be administered either before or after surgery. The choice depends on the clinical scenario and veterinary preference. - **Preoperative (Injection):** Administering robenacoxib subcutaneously at a dose of 2 mg/kg approximately 30 minutes before the procedure ensures that therapeutic levels are present as the cat emerges from anesthesia. This approach provides pre-emptive analgesia, which can reduce the overall pain experience. A study on ovariectomy used this exact protocol, administering robenacoxib 0.5 hours before premedication [4]. - **Postoperative (Tablets):** For at-home care, robenacoxib tablets are typically prescribed at a dose of 1.0 to 2.4 mg/kg once daily. This is often started the day after surgery or once the cat is eating and drinking normally. ### Recommended Dosage and Administration The approved dosage for robenacoxib in cats is consistent across studies: - **Oral Tablets:** 1.0 to 2.4 mg/kg, once every 24 hours [2][3]. The recommended minimum dosage is 1 mg/kg once daily [3]. - **Solution for Injection:** 2 mg/kg, administered subcutaneously [4]. For surgical pain, the duration of treatment is generally limited. The product label indicates use for a maximum of 3 days to control postoperative pain and inflammation associated with procedures like orthopedic surgery, ovariohysterectomy, and castration [5]. This short course is designed to manage acute pain without prolonging NSAID exposure. ### Multimodal Analgesia: A Team Approach Onsior is often used as part of a multimodal analgesic plan. This strategy combines drugs from different classes to target multiple pain pathways, improving efficacy and allowing for lower doses of each drug, thereby reducing side effects. - **Opioids:** Drugs like methadone are frequently used for premedication and intraoperative analgesia [10][4]. - **Local Anesthetics:** Techniques like the transversus abdominis plane (TAP) block or epidural injections provide regional anesthesia, significantly reducing the need for systemic analgesics [10][4]. - **Other NSAIDs:** Onsior can be used in place of other NSAIDs like ketoprofen, with studies showing similar efficacy and tolerability [2]. A study on sacrococcygeal epidural injections demonstrated this multimodal approach. Cats receiving an epidural with morphine and ropivacaine required rescue analgesia with robenacoxib far less frequently than the control group. In the control group, 83% of cats required robenacoxib, while only 21% of the epidural group did [10]. This highlights how effective regional techniques can be in reducing postoperative pain. --- ## Evidence-Based Efficacy of Onsior in Cats The efficacy of robenacoxib for controlling feline pain and inflammation is well-documented in clinical trials. ### Musculoskeletal Disorders A multicenter, randomized, masked field trial evaluated the efficacy of orally administered robenacoxib for acute pain and inflammation associated with musculoskeletal disorders in 155 cats. The study compared robenacoxib given at 1.0 to 2.4 mg/kg once daily, the same dose given twice daily, and ketoprofen at 1 mg/kg once daily. The results showed no significant differences among the treatment groups for any primary or secondary efficacy endpoints. All treatments were effective, and robenacoxib tablets administered once daily were as effective as the other protocols [2]. ### Surgical Pain Management The use of robenacoxib in surgical settings is supported by its inclusion as a rescue analgesic in several studies. In the ovariectomy study, all cats received robenacoxib (2 mg/kg SC) as a baseline analgesic. The study then evaluated the additional benefit of a TAP block. The results showed that the TAP block significantly reduced the need for rescue analgesia with methadone, demonstrating that robenacoxib alone was not always sufficient for more invasive procedures, but it provided a solid foundation of pain relief [4]. Similarly, in the epidural study, robenacoxib was the designated rescue analgesic. The fact that 21% of cats in the epidural group still required robenacoxib underscores its role as a reliable and effective option for breakthrough pain [10]. --- ## Safety Profile and Tolerability The safety of robenacoxib in cats has been extensively evaluated in target animal safety studies. ### High-Dose and Long-Term Safety In a pivotal safety study, healthy young cats were administered robenacoxib orally at dosages of 0 (placebo), 5, and 10 mg/kg once daily for 28 days, and in a second study at 0, 2, 6, and 10 mg/kg twice daily for 42 days. These dosages represent multiples of the recommended therapeutic dose. The results showed no toxicologically significant effects of robenacoxib. There were no adverse effects on general health, haematological (hematological) and clinical chemistry variables, urinalyses, or post-mortem findings. The study concluded that even at high doses, robenacoxib was well-tolerated [3]. ### Interchangeable Use of Formulations A safety study specifically investigated the interchangeable use of robenacoxib tablets and solution for injection in cats. Thirty-four healthy 4-month-old cats were randomized to receive either the maximum recommended dose or two to three times that dose. The cats underwent three 10-day treatment cycles, each comprising seven days of once-daily oral administration followed by three days of subcutaneous administration. The study found no significant safety concerns, supporting the flexibility of switching between the two formulations in a clinical setting [8]. ### Gastrointestinal and Renal Safety The high COX-2 selectivity of robenacoxib is believed to contribute to its favorable gastrointestinal safety profile. In the safety studies, there were no treatment-related changes in the gastrointestinal tract [3]. The short duration of COX-1 inhibition is also a key factor. Pharmacodynamic simulations predicted that at a dosage of 2 mg/kg, robenacoxib would result in only 5% inhibition of COX-1 while achieving 90% inhibition of COX-2 over the first 12 hours after administration [1]. This "sparing" of COX-1 helps maintain the protective mucus barrier in the stomach. While renal effects are a concern with all NSAIDs, the mixed faecal and urinary excretion of robenacoxib may offer some advantage in cats with marginal kidney function, although caution is still advised [6]. --- ## Onsior in Special Populations and Off-Label Uses While Onsior is labeled for use in domestic cats, its use has been explored in other species and situations. ### Non-Domestic Felids A pharmacokinetic study in tigers (Panthera tigris) investigated the use of robenacoxib. A single intramuscular dose of 0.25 mg/kg was found to maintain plasma concentrations above the therapeutic threshold (10 ng/ml, considered therapeutic in domestic cat studies) for up to 12 hours. This pilot study provides valuable data for potentially using robenacoxib in zoo and wildlife settings, although it is an off-label use [11]. ### Feline Injection-Site Sarcoma (FISS) Emerging research has explored the potential anti-cancer effects of robenacoxib. In vitro studies on primary cells derived from feline injection-site sarcomas (FISS) showed that robenacoxib inhibited cell viability, migration, and colony formation in a dose-dependent manner. It also enhanced cell apoptosis. These findings suggest that COX-2 inhibitors like robenacoxib could be potential adjuvant therapeutics against FISS, though this is a highly specialized area of research [12]. ### Avian and Other Species Robenacoxib has been studied in various avian species, including Hispaniolan parrots and geese. These studies have evaluated its pharmacokinetics at doses ranging from 2-10 mg/kg, but these are off-label uses and should not be extrapolated to domestic cats [5][13]. --- ## Contraindications and Precautions While robenacoxib is generally safe, it is not suitable for every cat. Your veterinarian will assess your cat's overall health before prescribing it. - **Known Hypersensitivity:** Cats with a known allergy to robenacoxib or other NSAIDs should not receive this medication. - **Pre-existing Conditions:** Use with caution in cats with pre-existing kidney, liver, or heart disease. The drug is excreted via both faecal and urinary routes, so impairment in either system could affect drug clearance [6]. - **Dehydration and Hypotension:** NSAIDs can affect renal blood flow. Cats that are dehydrated, in shock, or hypotensive during surgery are at higher risk of renal injury. Ensure adequate fluid therapy is provided. - **Gastrointestinal Ulceration:** Although the risk is lower than with non-selective NSAIDs, robenacoxib should be used with extreme caution in cats with a history of gastrointestinal ulceration or bleeding. - **Concurrent Medications:** Do not use robenacoxib with other NSAIDs or corticosteroids, as this can increase the risk of gastrointestinal and renal toxicity. --- ## Unsafe Home Remedies and Owner Misconceptions It is critical for pet owners to understand that human pain relievers are dangerous for cats. - **Ibuprofen (Advil, Motrin):** Highly toxic to cats, can cause severe gastrointestinal ulcers and acute kidney failure. - **Acetaminophen (Tylenol):** Extremely toxic to cats, causing damage to red blood cells (methemoglobinemia) and liver failure. - **Aspirin:** Can be toxic, leading to gastrointestinal bleeding and other issues. It is only used in very specific circumstances under strict veterinary supervision. Never attempt to dose your cat with any medication without explicit instructions from your veterinarian. The dose of Onsior is calculated based on your cat's weight, and using a "half a pill" guess can lead to underdosing (ineffective pain relief) or overdosing (toxicity). --- ## Prevention and Prognosis The prognosis for cats receiving Onsior for surgical pain is excellent. It is a highly effective and well-tolerated medication for managing acute pain. Most cats return to normal behavior (behaviour) within a few days of surgery. Prevention of surgical pain begins with a good perioperative plan. This includes: - **Pre-emptive Analgesia:** Administering pain relief before the surgical incision is made. - **Minimally Invasive Techniques:** When possible, using laparoscopic or other minimally invasive surgical techniques to reduce tissue trauma. - **Multimodal Approach:** Combining NSAIDs with opioids and local anesthetics to provide comprehensive pain control [10][4]. --- ## Limitations and When to Contact a Veterinarian This article provides a comprehensive overview of the Onsior robenacoxib feline dose and its use in surgical pain relief. However, it cannot replace professional veterinary advice. Breed-level differences in drug metabolism are not fully predictable, and individual cats may react differently to the same dose. **Contact your veterinarian immediately if you observe any of the following:** - **Gastrointestinal Signs:** Vomiting (especially if repeated), diarrhoea (diarrhea), or black, tarry stools. - **Decreased Appetite:** Refusal to eat for more than 24 hours after surgery. - **Lethargy:** Unusual weakness or depression. - **Changes in Urination:** Increased or decreased frequency, or difficulty urinating. - **Jaundice:** Yellowing of the gums, skin, or whites of the eyes. These could be signs of an adverse drug reaction or a surgical complication that requires prompt attention. --- ## Frequently Asked Questions ### 1. What is the exact dose of Onsior for a cat? The recommended dose of Onsior (robenacoxib) for cats is 1.0 to 2.4 mg/kg orally once daily, or 2 mg/kg subcutaneously as an injection. The exact dose for your cat will be calculated by your veterinarian based on their precise body weight. ### 2. How long does it take for Onsior to work in cats? Onsior is rapidly absorbed, with peak blood concentrations reached in less than one hour after oral or subcutaneous administration. You can expect to see pain relief and improved mobility within a few hours of administration. ### 3. How many days can a cat take Onsior? For surgical pain, Onsior is typically approved for a maximum of 3 days. For other conditions like musculoskeletal disorders, it may be used for 5 to 6 days. Always follow your veterinarian's instructions for the duration of treatment. ### 4. Can I give my cat Onsior and other pain medications together? Onsior is often used as part of a multimodal pain protocol that may include opioids (like methadone) and local anesthetics. However, you should never give your cat another NSAID or a corticosteroid while they are on Onsior, as this increases the risk of severe side effects. ### 5. What are the common side effects of Onsior in cats? Onsior is generally well-tolerated. The most common side effects are gastrointestinal and may include vomiting, diarrhoea (diarrhea), and decreased appetite. These are usually mild and transient. More serious side effects, such as kidney or liver issues, are rare but possible. ### 6. Is Onsior safe for cats with kidney disease? Onsior should be used with caution in cats with kidney disease. Because it is an NSAID, it can affect renal blood flow. Your veterinarian will assess your cat's kidney function before prescribing it and may recommend alternative pain relief options if there are concerns. ### 7. Can I use Onsior for my cat's chronic arthritis pain? Yes, robenacoxib has been shown to be effective for acute pain and inflammation associated with musculoskeletal disorders. However, for chronic conditions like arthritis, your veterinarian may discuss a long-term management plan, which could involve other therapies or a different dosing schedule. ### 8. What should I do if I miss giving my cat a dose of Onsior? If you miss a dose, give it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not give a double dose to make up for the missed one. --- ## Limitations and When to Contact a Veterinarian This article is educational and is not a substitute for veterinary diagnosis or treatment. The information provided here is based on published scientific literature and clinical guidelines. While the dose and safety profile of robenacoxib are well-established for the general feline population, it is impossible to predict how an individual cat will respond. Factors such as age, breed, genetic predisposition, and the presence of subclinical disease can influence drug metabolism and efficacy. Breed-level information, in particular, cannot predict individual drug reactions. **Always consult with a licensed veterinarian before administering any medication to your cat.** They can perform a thorough physical examination, run necessary diagnostic tests, and determine the safest and most effective pain management plan for your pet's specific needs. --- **References** ## References [1] Giraudel JM, Toutain PL, King JN, et al. "Differential inhibition of cyclooxygenase isoenzymes in the cat by the NSAID robenacoxib." *J Vet Pharmacol Ther.* 2009. URL: https://pubmed.ncbi.nlm.nih.gov/19161453/. [2] Giraudel JM, Gruet P, Alexander DG, et al. "Evaluation of orally administered robenacoxib versus ketoprofen for treatment of acute pain and inflammation associated with musculoskeletal disorders in cats." *Am J Vet Res.* 2010. URL: https://pubmed.ncbi.nlm.nih.gov/20594071/. [3] King JN, Hotz R, Reagan EL, et al. "Safety of oral robenacoxib in the cat." *J Vet Pharmacol Ther.* 2012. URL: https://pubmed.ncbi.nlm.nih.gov/21736587/. [4] Skouropoulou D, Lacitignola L, Centonze P, et al. "Perioperative analgesic effects of an ultrasound-guided transversus abdominis plane block with a mixture of bupivacaine and lidocaine in cats undergoing ovariectomy." *Vet Anaesth Analg.* 2018. URL: https://pubmed.ncbi.nlm.nih.gov/29627201/. [5] Penticoff HB, Tully TN, Vora D, et al. "Pharmacokinetics of a Single Oral Dose of Robenacoxib in Hispaniolan Parrots (Amazona ventralis)." *J Avian Med Surg.* 2025. URL: https://pubmed.ncbi.nlm.nih.gov/41420799/. [6] King JN, Jung M. "Determination of the route of excretion of robenacoxib (Onsior™) in cats and dogs: A pilot study." *J Vet Pharmacol Ther.* 2021. URL: https://pubmed.ncbi.nlm.nih.gov/33881783/. [7] Jung M, Lees P, Seewald W, et al. "Analytical determination and pharmacokinetics of robenacoxib in the [dog](/knowledge/veterinary-medicine/clinical-methods/dog)." *J Vet Pharmacol Ther.* 2009. URL: https://pubmed.ncbi.nlm.nih.gov/19161454/. [8] Heit MC, Stallons LJ, Seewald W, et al. "Safety evaluation of the interchangeable use of robenacoxib in commercially-available tablets and solution for injection in cats." *BMC Vet Res.* 2020. URL: https://pubmed.ncbi.nlm.nih.gov/32988403/. [9] Toutain CE, Heit MC, King SB, et al. "Safety evaluation of the interchangeable use of robenacoxib (Onsior™) tablets and solution for injection in dogs." *BMC Vet Res.* 2017. URL: https://pubmed.ncbi.nlm.nih.gov/29179750/. [10] Boesch JM, Wong S, Tobin K, et al. "Sacrococcygeal epidural injection of morphine and ropivacaine provides analgesia after feline ovariohysterectomy." *Am J Vet Res.* 2026. URL: https://pubmed.ncbi.nlm.nih.gov/41791227/. [11] Swanepoel L, Cox S, Cushing A. "PHARMACOKINETICS OF A SINGLE INTRAMUSCULAR DOSE OF ROBENACOXIB IN TIGERS (PANTHERA TIGRIS)." *J Zoo Wildl Med.* 2026. URL: https://pubmed.ncbi.nlm.nih.gov/42405730/. [12] Lu CH, Yu SH, Wu CH, et al. "Effects of selective cyclooxygenase-2 inhibitor robenacoxib on primary cells derived from feline injection-site sarcoma." *J Cell Mol Med.* 2023. URL: https://pubmed.ncbi.nlm.nih.gov/37334757/. [13] Fadel C, Łebkowska-Wieruszewska B, Lisowski A, et al. "Disposition kinetics of robenacoxib following intravenous and oral administration in geese (Anser anser domesticus)." *J Vet Pharmacol Ther.* 2023. URL: https://pubmed.ncbi.nlm.nih.gov/37312265/. [14] Wilson DV, Pascoe PJ. "Pain and analgesia following onychectomy in cats: a systematic review." *Vet Anaesth Analg.* 2016. URL: https://pubmed.ncbi.nlm.nih.gov/26457818/. [15] Toutain CE, Brossard P, King SB, et al. "Six-month safety evaluation of robenacoxib tablets (Onsior™) in dogs after daily oral administrations." *BMC Vet Res.* 2018. URL: https://pubmed.ncbi.nlm.nih.gov/30119677/. [16] Bennett D, Eckersall PD, Waterston M, et al. "The effect of robenacoxib on the concentration of C-reactive protein in synovial fluid from dogs with osteoarthritis." *BMC Vet Res.* 2013. URL: https://pubmed.ncbi.nlm.nih.gov/23452411/. --- ## Sources 1. [Determination of the route of excretion of robenacoxib (Onsior™) in cats and dogs: A pilot study.](https://pubmed.ncbi.nlm.nih.gov/33881783/) 2. [Evaluation of orally administered robenacoxib versus ketoprofen for treatment of acute pain and inflammation associated with musculoskeletal disorders in cats.](https://pubmed.ncbi.nlm.nih.gov/20594071/) 3. [Safety evaluation of the interchangeable use of robenacoxib in commercially-available tablets and solution for injection in cats.](https://pubmed.ncbi.nlm.nih.gov/32988403/) 4. [Safety evaluation of the interchangeable use of robenacoxib (Onsior™) tablets and solution for injection in dogs.](https://pubmed.ncbi.nlm.nih.gov/29179750/) 5. [Pain and analgesia following onychectomy in cats: a systematic review.](https://pubmed.ncbi.nlm.nih.gov/26457818/) 6. [PHARMACOKINETICS OF A SINGLE INTRAMUSCULAR DOSE OF ROBENACOXIB IN TIGERS (PANTHERA TIGRIS).](https://pubmed.ncbi.nlm.nih.gov/42405730/) 7. [Pharmacokinetics of a Single Oral Dose of Robenacoxib in Hispaniolan Parrots (Amazona ventralis).](https://pubmed.ncbi.nlm.nih.gov/41420799/) 8. [Effects of selective cyclooxygenase-2 inhibitor robenacoxib on primary cells derived from feline injection-site sarcoma.](https://pubmed.ncbi.nlm.nih.gov/37334757/) 9. [Six-month safety evaluation of robenacoxib tablets (Onsior™) in dogs after daily oral administrations.](https://pubmed.ncbi.nlm.nih.gov/30119677/) 10. [Safety of oral robenacoxib in the cat.](https://pubmed.ncbi.nlm.nih.gov/21736587/) 11. [Differential inhibition of cyclooxygenase isoenzymes in the cat by the NSAID robenacoxib.](https://pubmed.ncbi.nlm.nih.gov/19161453/) 12. [Sacrococcygeal epidural injection of morphine and ropivacaine provides analgesia after feline ovariohysterectomy.](https://pubmed.ncbi.nlm.nih.gov/41791227/) 13. [Perioperative analgesic effects of an ultrasound-guided transversus abdominis plane block with a mixture of bupivacaine and lidocaine in cats undergoing ovariectomy.](https://pubmed.ncbi.nlm.nih.gov/29627201/) 14. [Analytical determination and pharmacokinetics of robenacoxib in the dog.](https://pubmed.ncbi.nlm.nih.gov/19161454/) 15. [Disposition kinetics of robenacoxib following intravenous and oral administration in geese (Anser anser domesticus).](https://pubmed.ncbi.nlm.nih.gov/37312265/) 16. [The effect of robenacoxib on the concentration of C-reactive protein in synovial fluid from dogs with osteoarthritis.](https://pubmed.ncbi.nlm.nih.gov/23452411/)

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