# Moderna and Merck Report Positive Phase 3 Results for mRNA Cancer Vaccine

Merck & Co. and Moderna announced last month that their mRNA cancer vaccine extended patient survival in a phase 3 clinical trial. The result confirms years of effort by the two companies and has renewed optimism for the field of personalized medicine.

The vaccine is designed to teach the immune system to recognize and attack cancer cells carrying specific mutations from a patient's own tumor. The phase 3 win is the strongest evidence to date that such a personalized approach can improve outcomes in late-stage disease.

**Context for the life sciences**

mRNA technology, widely known for its use in COVID-19 vaccines, is now demonstrating potential in oncology. Personalized cancer vaccines require sequencing a patient's tumor, identifying unique mutations, and manufacturing a custom mRNA therapy, an individualized manufacturing process that was once considered impractical. This trial result suggests that the approach is feasible and effective in a controlled setting. For the broader biotech industry, the success could accelerate investment in other personalized mRNA applications, including vaccines for additional cancer types and rare diseases. It also highlights the growing convergence of genomics, immunology, and advanced manufacturing in modern medicine.

Source: [original report](https://www.fiercebiotech.com/biotech/moderna-merck-re-invigorating-mrna-cancer-vaccine-therapy)